Adrenoceptors Modulate Cholinergic Synaptic Transmission at the Neuromuscular Junction
| Autor: | Venera Khuzakhmetova, Svetlana Dmitrieva, A. N. Tsentsevitsky, Ellya Bukharaeva |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Sympathomimetics
adrenoreceptors QH301-705.5 Neuromuscular transmission Review Neurotransmission Receptors Nicotinic acetylcholine quantal release Synaptic Transmission Catalysis Neuromuscular junction Inorganic Chemistry adrenergic drugs Postsynaptic potential Medicine Animals Humans Biology (General) Physical and Theoretical Chemistry QD1-999 Molecular Biology Spectroscopy Acetylcholine receptor acetylcholine receptor neuromuscular junction business.industry Organic Chemistry General Medicine Acetylcholine Cholinergic Neurons Computer Science Applications Receptors Adrenergic Chemistry medicine.anatomical_structure Cholinergic business Neuroscience medicine.drug |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 4611, p 4611 (2021) |
| ISSN: | 1422-0067 |
| Popis: | Adrenoceptor activators and blockers are widely used clinically for the treatment of cardiovascular and pulmonary disorders. More recently, adrenergic agents have also been used to treat neurodegenerative diseases. Recent studies indicate a location of sympathetic varicosities in close proximity to neuromuscular junctions. The pressing question is whether there could be any effects of endo- or exogenous catecholamines on cholinergic neuromuscular transmission. It was shown that the pharmacological stimulation of adrenoceptors, as well as sympathectomy, can affect both acetylcholine release from motor nerve terminals and the functioning of postsynaptic acetylcholine receptors. In this review, we discuss the recent data regarding the effects of adrenergic drugs on neurotransmission at the neuromuscular junction. The elucidation of the molecular mechanisms by which the clinically relevant adrenomimetics and adrenoblockers regulate quantal acetylcholine release from the presynaptic nerve terminals and postsynaptic sensitivity may help in the design of highly effective and well-tolerated sympathomimetics for treating a number of neurodegenerative diseases accompanied by synaptic defects. |
| Databáze: | OpenAIRE |
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