Angiogenic cytokines can reflect the synovitis severity and treatment response to biologics in rheumatoid arthritis

Autor: Jin-Sun Kong, Wan-Uk Kim, Seung-Ah Yoo, Saseong Lee, Jingchun Jin, Jung Hee Koh, Ji-Won Kim
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
musculoskeletal diseases
medicine.medical_specialty
Autoimmune diseases
Clinical Biochemistry
QD415-436
Gastroenterology
Severity of Illness Index
Biochemistry
Article
Arthritis
Rheumatoid
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Synovitis
medicine
Synovial fluid
Humans
Rheumatoid arthritis
skin and connective tissue diseases
Molecular Biology
030203 arthritis & rheumatology
Biological Products
medicine.diagnostic_test
Neovascularization
Pathologic
business.industry
Abatacept
Diagnostic markers
medicine.disease
Vascular endothelial growth factor
030104 developmental biology
Treatment Outcome
chemistry
Erythrocyte sedimentation rate
Antirheumatic Agents
Molecular Medicine
Biomarker (medicine)
Cytokines
Medicine
Inflammation Mediators
business
Biomarkers
medicine.drug
Blood sampling
Zdroj: Experimental and Molecular Medicine, Vol 52, Iss 5, Pp 843-853 (2020)
Experimental & Molecular Medicine
ISSN: 2092-6413
1226-3613
Popis: Angiogenesis and synoviocyte hyperplasia, called ‘pannus,’ are pathologic hallmarks of rheumatoid arthritis (RA). To determine the clinical significance of angiogenic cytokines in RA, the levels of pro-angiogenic cytokines, including VEGF, placenta growth factor (PlGF), and IL-6, were measured in the synovial fluid (SF, n = 54) and sera of RA patients (n = 157) using ELISA. Patients (n = 103) with disease activity score 28 (DAS28) > 3.2, which indicates moderate to high RA activity, underwent follow-up blood sampling at 6 months after treatment with conventional disease-modifying anti-rheumatic drugs (c-DMARD) or biologic DMARD (b-DMARD) including an anti-TNFα antibody, an anti-IL-6 antibody, and abatacept. Ultrasonography (US) was performed on affected joints to define the synovitis severity at the time of sampling. Consequently, in the SF of RA patients, PlGF and IL-6 levels correlated well with synovitis severity determined by US. In RA sera, VEGF and IL-6 levels were elevated in proportion to synovitis severity, correlating with conventional markers for disease activity, including ESR, CRP, and DAS28. In c-DMARD users (n = 53), serially monitored levels of serum VEGF, IL-6, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) all decreased in good and moderate responders but not in nonresponders. In b-DMARD users (n = 49), only serum VEGF well represented the treatment response, while CRP nonspecifically decreased irrespective of the treatment outcome. By multivariable analysis, serum ΔVEGF, but not ΔESR or ΔCRP, was an independent factor associated with good and moderate responses to DMARD. In summary, the angiogenic cytokines PlGF and VEGF represent the synovitis severity of RA assessed by US. In patients receiving b-DMARD, serum VEGF may be more valuable than CRP in reflecting the treatment response.
Rheumatoid arthritis: growth factor shows diagnostic potential A growth factor implicated in the development of new blood vessels could serve as an indicator of disease severity and treatment response in people with rheumatoid arthritis (RA). A team led by Wan-Uk Kim from the Catholic University of Korea, Seoul, South Korea, and Jingchun Jin from Yanbian University Hospital, Yanji, China, tested RA patients for signaling proteins that direct the formation of blood vessels. They found several proteins whose levels, either in blood or joint fluid, tracked closely with the severity of joint inflammation. The blood levels of only one protein, vascular endothelial growth factor (VEGF), reliably dropped in those who responded favorably to drug treatments but not in those who derived little benefit from anti-rheumatic therapy. The findings highlight the diagnostic potential of blood testing for VEGF as a biomarker of RA activity.
Databáze: OpenAIRE
Externí odkaz: