Associations between psychosis endophenotypes across brain functional, structural, and cognitive domains
| Autor: | Blakey R., Ranlund S., Zartaloudi E., Cahn W., Calafato S., Colizzi M., Crespo-Facorro B., Daniel C., Díez-Revuelta Á., Di Forti M., Group, Iyegbe C., Jablensky A., Jones R., Hall M.-H., Kahn R., Kalaydjieva L., Kravariti E., Lin K., McDonald C., McIntosh A.M., Peic, Picchioni M., Powell J., Presman A., Rujescu D., Schulze K., Shaikh M., Thygesen J.H., Toulopoulou T., Van Haren N., Van Os J., Walshe M., Wtccc2, Murray R.M., Bramon E. |
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| Přispěvatelé: | Toulopoulou, Timothea, RS: MHeNs - R2 - Mental Health, MUMC+: MA Psychiatrie (3), Psychiatrie & Neuropsychologie |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Unaffected relatives Verbal memory Audiology Neuropsychological Tests Developmental psychology 0302 clinical medicine DURATION MISMATCH NEGATIVITY Memory span 80 and over P300 Applied Psychology VERBAL WORKING-MEMORY Aged 80 and over education.field_of_study Lateral ventricular volume PSYCHIATRIC-DISORDERS Brain Cognition BIPOLAR DISORDER Middle Aged unaffected relatives Magnetic Resonance Imaging Electrophysiology Psychiatry and Mental health Schizophrenia Female Psychology Adult Psychosis medicine.medical_specialty Adolescent Endophenotypes Population HEALTHY CONTROLS EVENT-RELATED POTENTIALS verbal memory SCHIZOPHRENIA-PATIENTS Article working memory schizophrenia Aged Case-Control Studies Event-Related Potentials P300 Humans Linear Models Nerve Net Psychotic Disorders Young Adult 03 medical and health sciences medicine Bipolar disorder 1ST-EPISODE PSYCHOSIS education Working memory medicine.disease 030227 psychiatry HIGH-RISK Endophenotype 030217 neurology & neurosurgery |
| Zdroj: | Psychological Medicine Psychological Medicine, 48(8), 1325-1340. Cambridge University Press |
| ISSN: | 0033-2917 |
| Popis: | BackgroundA range of endophenotypes characterise psychosis, however there has been limited work understanding if and how they are inter-related.MethodsThis multi-centre study includes 8754 participants: 2212 people with a psychotic disorder, 1487 unaffected relatives of probands, and 5055 healthy controls. We investigated cognition [digit span (N= 3127), block design (N= 5491), and the Rey Auditory Verbal Learning Test (N= 3543)], electrophysiology [P300 amplitude and latency (N= 1102)], and neuroanatomy [lateral ventricular volume (N= 1721)]. We used linear regression to assess the interrelationships between endophenotypes.ResultsThe P300 amplitude and latency were not associated (regression coef. −0.06, 95% CI −0.12 to 0.01,p= 0.060), and P300 amplitude was positively associated with block design (coef. 0.19, 95% CI 0.10–0.28,p< 0.001). There was no evidence of associations between lateral ventricular volume and the other measures (allp> 0.38). All the cognitive endophenotypes were associated with each other in the expected directions (allp< 0.001). Lastly, the relationships between pairs of endophenotypes were consistent in all three participant groups, differing for some of the cognitive pairings only in the strengths of the relationships.ConclusionsThe P300 amplitude and latency are independent endophenotypes; the former indexing spatial visualisation and working memory, and the latter is hypothesised to index basic processing speed. Individuals with psychotic illnesses, their unaffected relatives, and healthy controls all show similar patterns of associations between endophenotypes, endorsing the theory of a continuum of psychosis liability across the population. |
| Databáze: | OpenAIRE |
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