Platelet-derived growth factor is mitogenic for O-2Aadult progenitor cells
| Autor: | Guus Wolswijk, Mark Noble, Peter N. Riddle |
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| Rok vydání: | 1991 |
| Předmět: |
Time Factors
Platelet-derived growth factor medicine.medical_treatment Vimentin Antibodies Cellular and Molecular Neuroscience chemistry.chemical_compound Cell Movement medicine Animals Antigens Progenitor cell Platelet-Derived Growth Factor biology Stem Cells Growth factor Antibodies Monoclonal Oligodendrocyte Culture Media Cell biology Oligodendroglia Phenotype medicine.anatomical_structure Neurology chemistry Immunology biology.protein Neuroglia Mitogens Cell Division Platelet-derived growth factor receptor Astrocyte |
| Zdroj: | Glia. 4:495-503 |
| ISSN: | 1098-1136 0894-1491 |
| DOI: | 10.1002/glia.440040509 |
| Popis: | We report that platelet-derived growth factor (PDGF) is a potent mitogen for oligodendrocyte type-2 astrocyte (O-2A) progenitor cells derived from the optic nerves of adult rats. Moreover, O-2Aadult progenitors cultured in PDGF express the range of properties we have described previously for O-2Aadult progenitors cultured in the presence of type-1 astrocytes. Similarly, previous studies have demonstrated that PDGF is able to mimic the influence of type-1 astrocytes on O-2Aperinatal progenitors. Specifically, O-2Aadult progenitors and O-2Aperinatal progenitors exposed to PDGF express differences in average cell cycle time (59 +/- 5 h for O-2Aadult progenitors versus 20 +/- 6 h for O-2Aperinatal progenitors), average rate of migration (4.1 +/- 0.6 microns h-1 versus 24.6 +/- 5.4 microns h-1), morphology (unipolar versus bipolar), and antigenic phenotype (04+ vimentin- versus 04- vimentin+). Thus, our present results indicate that a single signalling molecule secreted by type-1 astrocytes produces markedly different cellular behaviours in two related O-2A progenitor populations. |
| Databáze: | OpenAIRE |
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