Usefulness of p16 for differentiating primary pulmonary squamous cell carcinoma from cervical squamous cell carcinoma metastatic to the lung
| Autor: | Chih Wei Wang, Yun Hui Teng, Chih Teng Yu, Yi Cheng Wu, Tzu-I Wu, Chyong-Huey Lai, Szu Ying Chin, Tse Ching Chen |
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| Rok vydání: | 2009 |
| Předmět: |
Pathology
medicine.medical_specialty Lung Neoplasms Uterine Cervical Neoplasms Metastasis Diagnosis Differential Predictive Value of Tests Carcinoma medicine Biomarkers Tumor Humans Basal cell carcinoma neoplasms Cervix Papillomaviridae Cyclin-Dependent Kinase Inhibitor p16 Cervical cancer Lung business.industry Cancer General Medicine medicine.disease stomatognathic diseases medicine.anatomical_structure Epidermoid carcinoma Fluorescent Antibody Technique Direct DNA Viral Carcinoma Squamous Cell Female business |
| Zdroj: | American journal of clinical pathology. 131(5) |
| ISSN: | 1943-7722 |
| Popis: | To date, there is no reliable immunohistochemical marker that discriminates between primary pulmonary squamous cell carcinoma (SCC) and cervical SCC metastatic to the lung. In this study, immunohistochemical staining of p16 was performed on 33 primary pulmonary SCCs, 48 primary cervical SCCs, and 17 cases of cervical SCC with pulmonary metastasis. Expression of p16 was noted in 47 cases of cervical SCC (47/48 [98%]), and all were strongly stained. Of the 7 cases of primary pulmonary SCC (7/33 [21%]) in which p16 expression was detected, 3 were weakly positive, 1 was moderately positive, and 3 were strongly positive. Among these p16+ pulmonary SCCs, only 1 showed detectable human papillomavirus DNA. Of the 17 cases of cervical SCC with pulmonary metastasis, all of the pulmonary and cervical tumors were positive for p16. p16 is a useful marker for the discrimination between cervical and pulmonary SCCs. The performance of p16 staining at different cutoff values was also compared. |
| Databáze: | OpenAIRE |
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