Association between enterocyte injury and fluid balance in patients with septic shock: a post hoc exploratory analysis of a prospective observational study

Autor:	Hiroshi Araki, Shuntaro Sato, Hiroyuki Funaoka, Tetsuya Hara, Motohiro Sekino, Rintaro Yano, Haruka Yokoyama, Takashi Egashira, Taiga Ichinomiya, Ushio Higashijima, Sojiro Matsumoto
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Male medicine.medical_specialty Time Factors Renal function Fluid administration Fatty Acid-Binding Proteins Gastroenterology Severity of Illness Index law.invention Sepsis law Anesthesiology Internal medicine Septic shock medicine Humans Intensive care unit RD78.3-87.3 Prospective Studies Aged Enterocyte damage business.industry Research Middle Aged Water-Electrolyte Balance medicine.disease Shock Septic Confidence interval Intestinal mucosal cell Intensive Care Units Anesthesiology and Pain Medicine Enterocytes Fluid volume Shock (circulatory) Intestinal fatty acid-binding protein Biomarker (medicine) Female medicine.symptom business
Zdroj:	BMC Anesthesiology, Vol 21, Iss 1, Pp 1-8 (2021) BMC Anesthesiology
ISSN:	1471-2253
Popis:	Background: The required fluid volume differs among patients with septic shock. Enterocyte injury caused by shock may increase the need for fluid by triggering a systematic inflammatory response or an ischemia-reperfusion injury in the presence of intestinal ischemia/necrosis. This study aimed to evaluate the association between enterocyte injury and positive fluid balance in patients with septic shock. Methods: This study was a post hoc exploratory analysis of a prospective observational study that assessed the association between serum intestinal fatty acid-binding protein, a biomarker of enterocyte injury, and mortality in patients with septic shock. Intestinal fatty acid-binding protein levels were recorded on intensive care unit admission, and fluid balance was monitored from intensive care unit admission to Day 7. The association between intestinal fatty acid-binding protein levels at admission and the infusion balance during the early period after intensive care unit admission was evaluated. Multiple linear regression analysis, with adjustments for severity score and renal function, was performed. Results: Overall, data of 57 patients were analyzed. Logarithmically transformed intestinal fatty acid-binding protein levels were significantly associated with cumulative fluid balance per body weight at 24 and 72 h post-intensive care unit admission both before (Pearson’s r = 0.490 [95% confidence interval: 0.263–0.666]; P BMC Anesthesiology, 21, art. no. 293; 2021
Databáze:	OpenAIRE
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