Study on a possible effect of four longevity candidate genes (ACE, PON1, PPAR-gamma and APOE) on human fertility
| Autor: | L Ulizzi, Rosa Maria Corbo, Renato Scacchi, Laura Piombo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Male
Apolipoprotein E Aging medicine.medical_specialty Candidate gene Genotype media_common.quotation_subject Longevity APOE polymorphism Reproductive Behavior Fertility Biology PPAR-gamma polymorphism Apolipoproteins E Human fertility Pleiotropy Antagonist pleiotropy Internal medicine Renin medicine Humans Allele Aged media_common Aged 80 and over Aryldialkylphosphatase PPAR gamma Endocrinology PPARG Population study longevity fertility APOE Female lipids (amino acids peptides and proteins) Geriatrics and Gerontology Gerontology |
| Zdroj: | Biogerontology (Dordrecht) 9 (2008): 317–323. doi:10.1007/s10522-008-9143-9 info:cnr-pdr/source/autori:Corbo RM; Ulizzi L; Piombo L; Scacchi R./titolo:Study on a possible effect of four longevity candidate genes (ACE, PON1, PPAR-gamma and APOE) on human fertility/doi:10.1007%2Fs10522-008-9143-9/rivista:Biogerontology (Dordrecht)/anno:2008/pagina_da:317/pagina_a:323/intervallo_pagine:317–323/volume:9 |
| DOI: | 10.1007/s10522-008-9143-9 |
| Popis: | The present study investigated for a possible effect on fertility of four longevity candidate genes (ACE, PON1, PPAR-gamma, APOE) in order to determine whether they have a pleiotropic action at different life ages. The study population was 151 healthy unrelated subjects. Only PPAR-gamma and APOE showed an effect on fertility. The PPAR-gamma Pro/Ala genotype, which had showed an association with longevity only in men, was found associated only in men with having produced more children (6.1+/-3.3) than the Pro/Pro genotype (3.3+/-1.9; P=0.001). APOE*2 allele, which has been consistently associated with longevity, was confirmed to be associated with the lowest fertility (P=0.03). The logistic regression analysis indicated that APOE and PPAR-gamma polymorphisms may be considered independent determinants of reproductive efficiency. These data suggest that the APOE*2 allele follows the model of antagonist pleiotropy, while the PPAR-gamma Pro/Ala genotype seems to exert beneficial effects both early in life and in advanced age in a gender-specific way. |
| Databáze: | OpenAIRE |
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