In vivo deep brain imaging of rats using oral-cavity illuminated photoacoustic computed tomography
| Autor: | Ruiying Zhang, Li Lin, Jun Xia, Terence T. W. Wong, Lihong V. Wang |
|---|---|
| Přispěvatelé: | Oraevsky, Alexander A., Wang, Lihong V. |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Pathology
medicine.medical_specialty Optical fiber Materials science Research Papers: Imaging Biomedical Engineering Photoacoustic imaging in biomedicine Computed tomography Neuroimaging Oral cavity law.invention Biomaterials Photoacoustic Techniques Optics law In vivo medicine Animals Tomography Medulla Optical Fibers medicine.diagnostic_test business.industry Brain Atomic and Molecular Physics and Optics Electronic Optical and Magnetic Materials Rats Photoacoustic Doppler effect Skull medicine.anatomical_structure Transducer business Preclinical imaging Biomedical engineering |
| Popis: | We demonstrate, by means of internal light delivery, photoacoustic imaging of the deep brain of rats in vivo . With fiber illumination via the oral cavity, we delivered light directly into the bottom of the brain, much more than can be delivered by external illumination. The study was performed using a photoacoustic computed tomography (PACT) system equipped with a 512-element full-ring transducer array, providing a full two-dimensional view aperture. Using internal illumination, the PACT system provided clear cross sectional photoacoustic images from the palate to the middle brain of live rats, revealing deep brain structures such as the hypothalamus, brain stem, and cerebral medulla. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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