Functional Val66Met polymorphism of Brain-derived neurotrophic factor in type 2 diabetes with depression in Han Chinese subjects
| Autor: | Xue-jun Bai, Baocheng Chang, Chun-jun Li, Liming Chen, He-Chao Li, Pei Sun, Jian-xin Zhou |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
China medicine.medical_specialty Neurology Genotype Cognitive Neuroscience Type 2 diabetes Polymorphism Single Nucleotide Pathogenesis Behavioral Neuroscience Asian People Gene Frequency Polymorphism (computer science) Neurotrophic factors Internal medicine medicine Humans Polymorphism Psychiatry Allele frequency Alleles Biological Psychiatry Depression (differential diagnoses) Type 2 diabetes (T2DM) Brain-derived neurotrophic factor Depressive Disorder Depression Brain-Derived Neurotrophic Factor Research General Medicine Middle Aged medicine.disease Endocrinology Diabetes Mellitus Type 2 Female Brain-derived neurotrophic factor (BDNF) Psychology |
| Zdroj: | Behavioral and Brain Functions : BBF |
| ISSN: | 1744-9081 |
| DOI: | 10.1186/1744-9081-9-34 |
| Popis: | BackgroundBrain-derived neurotrophic factor (BDNF) has been implicated in the pathogenesis of major depression. Individuals with type 2 diabetes (T2DM) have a high prevalence of major depression and low levels of BDNF. We therefore explored whether the BDNF Val66Met polymorphism is associated with co-morbid depression and whether depression affects the serum levels of BDNF in a Han Chinese subjects with T2DM.MethodsA Total of 296 T2DM patients and 70 healthy volunteers (Health control, HC group) were recruited in this study. T2DM patients were divided into two subgroups: depressive diabetes group (DDM group, n = 64) and non-depressive diabetes group (NDDM group, n = 232), according to the presence or the absence of depression assessed by Center for Epidemiologic Studies Depression Scale (CES-D) and Patient Health Questionnaire-9 (PHQ-9). Val66Met polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP). Serum BDNF levels were measured by ELISA kit.ResultsIn this study, 21.6% (64/296) patients with T2DM had depression. The BDNF Val66Met genotype distributions were statistically different among the three groups (χ2 = 7.39, p ConclusionsThe BDNF Val66Met polymorphism might be implicated in the pathogenesis of depression in T2DM by decreasing serum BDNF levels in Han Chinese Subjects. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink