Synthesis, characterization and biological evaluation of mononuclear Co(II), Ni(II), Cu(II) and Pd(II) complexes with new N2O2 Schiff base ligands
| Autor: | Muralidhar Reddy Puchakayala, Anren Hu, Shobha Rani Kongara, Geeta Budige, Ravinder Vadde |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Stereochemistry
Drug Evaluation Preclinical chemistry.chemical_element Microbial Sensitivity Tests medicine.disease_cause Ligands Metal chemistry.chemical_compound Coordination Complexes Nickel Drug Discovery medicine Escherichia coli Schiff Bases Schiff base General Chemistry General Medicine Cobalt Copper Anti-Bacterial Agents chemistry visual_art visual_art.visual_art_medium Nitrogen Oxides Antibacterial activity Palladium Nuclear chemistry |
| Zdroj: | Chemicalpharmaceutical bulletin. 59(2) |
| ISSN: | 1347-5223 |
| Popis: | New tetradentate N(2)O(2) donor Schiff bases and their mononuclear Co(II), Ni(II), Cu(II), and Pd(II) complexes were synthesized and characterized extensively by IR, (1)H-, (13)C-NMR, mass, ESR, conductivity measurements, elemental and thermal analysis. Specifically the magnetic and electronic spectral measurements demonstrate the octahedral structures of cobalt(II), nickel(II) complexes and square planar geometries of copper(II), palladium(II) complexes. All the ligands and complexes were screened for their in vitro antibacterial activity against two gram-positive bacteria (Bacillus subtilis, Staphylococcus aureus) and two gram-negative bacteria (Escherichia coli, Klebsiella pneumonia). In this study, Pd(II) complexes exhibited potent antibacterial activity against B. subtilis, S. aureus whereas other metal complexes also exerted good activity towards all tested strains even than standard drugs streptomycin and ampicillin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|