Virological Outcome After Choice of Antiretroviral Regimen Guided by Proviral HIV-1 DNA Genotyping in a Real-Life Cohort of HIV-Infected Patients
| Autor: | Macha Tetart, Agnès Meybeck, Anne Boucher, Faiza Ajana, Laurence Bocket, Philippe Choisy, Thomas Huleux, Olivier Robineau, Enagnon Kazali Alidjinou |
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| Rok vydání: | 2020 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Genotype Anti-HIV Agents Proviral dna HIV Infections Cohort Studies 03 medical and health sciences 0302 clinical medicine Internal medicine Antiretroviral Therapy Highly Active Drug Resistance Viral medicine Hiv infected patients Humans Clinical significance 030212 general & internal medicine Viremia Hiv 1 dna Genotyping Retrospective Studies 030505 public health business.industry Public Health Environmental and Occupational Health Middle Aged Viral Load CD4 Lymphocyte Count Regimen Infectious Diseases Treatment Outcome Anti-Retroviral Agents Cohort Genotypic resistance HIV-1 Female 0305 other medical science business |
| Zdroj: | AIDS patient care and STDs. 34(2) |
| ISSN: | 1557-7449 |
| Popis: | Issues have been raised concerning clinical relevance of HIV-1 proviral DNA genotypic resistance test (DNA GRT). To assess impact of DNA GRT on choice of antiretroviral therapy (ART) and subsequent virological outcome, we retrospectively reviewed decision-making and viral load (VL) evolution following DNA GRT performed in our center between January 2012 and December 2017, except those prescribed within the framework of a clinical trial. A total of 304 DNA GRTs were included, 185 (62%) performed in a context of virological success. Only 34% of tests were followed by ART change, more frequently in situation of virological success (39% vs. 26% |
| Databáze: | OpenAIRE |
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