microRNA Decay: Refining microRNA Regulatory Activity
| Autor: | Michael P. Gantier, Genevieve Pepin |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Ribonuclease III
Genetics Lin-4 microRNA precursor Messenger RNA RNase P Cell RNA General Medicine Computational biology Biology Exosome DEAD-box RNA Helicases MicroRNAs medicine.anatomical_structure Gene Expression Regulation Protein Biosynthesis microRNA Emergency Medicine medicine Humans Orthopedics and Sports Medicine Secretion RNA Messenger RNA Processing Post-Transcriptional |
| Zdroj: | MicroRNA. 5:167-174 |
| ISSN: | 2211-5366 |
| DOI: | 10.2174/2211536605666161027165915 |
| Popis: | MicroRNAs (miRNAs) are short 19-25 nucleotide RNA molecules that impact on most biological processes by regulating the efficiency of messenger RNA (mRNA) translation. To date, most research activities have been focused on the control of miRNA expression and its functional consequences. Nonetheless, much remains unknown about the mechanisms affecting the level of specific miRNAs in the cell, a critical feature impacting their regulatory activity. This review focuses on the factors that regulate the abundance of miRNAs, including synthesis, post-transcriptional modifications, nucleases, target binding, and secretion. |
| Databáze: | OpenAIRE |
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