Three Rules Explain Transgenerational Small RNA Inheritance in C. elegans
| Autor: | Oded Rechavi, Leah Houri-Zeevi, Olga Antonova, Yael Korem Kohanim |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Persistence (psychology)
Genetics 0303 health sciences Small RNA education.field_of_study Population Inheritance Patterns Inheritance (genetic algorithm) Biology Article General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Transgenerational epigenetics RNA interference Animals Gene silencing RNA Interference RNA Small Interfering Caenorhabditis elegans Caenorhabditis elegans Proteins education 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | Cell |
| ISSN: | 0092-8674 |
| DOI: | 10.1016/j.cell.2020.07.022 |
| Popis: | Summary Experiences trigger transgenerational small RNA-based responses in C. elegans nematodes. Dedicated machinery ensures that heritable effects are reset, but how the responses segregate in the population is unknown. We show that isogenic individuals differ dramatically in the persistence of transgenerational responses. By examining lineages of more than 20,000 worms, three principles emerge: (1) The silencing each mother initiates is distributed evenly among her descendants; heritable RNAi dissipates but is uniform in every generation. (2) Differences between lineages arise because the mothers that initiate heritable responses stochastically assume different “inheritance states” that determine the progeny’s fate. (3) The likelihood that an RNAi response would continue to be inherited increases the more generations it lasts. The inheritance states are determined by HSF-1, which regulates silencing factors and, accordingly, small RNA levels. We found that, based on the parents’ inheritance state, the descendants’ developmental rate in response to stress can be predicted. Graphical Abstract Highlights • Segregation of inherited small RNA responses follows three simple principles • Mothers stochastically assume inheritance states that determine the progeny’s fate • HSF-1 defines the states and regulates silencing factors and small RNA levels • The mothers’ inheritance state can predict the progeny’s response to stress Transgenerational RNAi responses in C.elegans exhibit distinct segregation patterns described by three simple rules. |
| Databáze: | OpenAIRE |
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