Relationship between natural killer cell activity and glucose control in patients with type 2 diabetes and prediabetes

Autor: Sang Bae Lee, Kahui Park, Jong Suk Park, Chul Woo Ahn, Shinae Kang, Ji Sun Nam, Jung Hye Kim
Rok vydání: 2019
Předmět:
Blood Glucose
Male
0301 basic medicine
medicine.medical_specialty
Endocrinology
Diabetes and Metabolism
medicine.medical_treatment
Natural killer cell activity
Type 2 diabetes
Diseases of the endocrine glands. Clinical endocrinology
Prediabetic State
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Insulin resistance
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
Humans
Prediabetes
Glycated Hemoglobin
Type 2 diabetes mellitus
business.industry
Insulin
Type 2 Diabetes Mellitus
Articles
General Medicine
Middle Aged
RC648-665
Prognosis
medicine.disease
Killer Cells
Natural
Clinical Science and Care
Cross-Sectional Studies
030104 developmental biology
Endocrinology
Diabetes Mellitus
Type 2
chemistry
Hyperglycemia
030220 oncology & carcinogenesis
Homeostatic model assessment
Original Article
Female
Glycated hemoglobin
business
Biomarkers
Follow-Up Studies
Zdroj: Journal of Diabetes Investigation
Journal of Diabetes Investigation, Vol 10, Iss 5, Pp 1223-1228 (2019)
ISSN: 2040-1124
2040-1116
Popis: Aims/Introduction Natural killer (NK) cells are cytotoxic lymphocytes critical to human immunity. Previous studies showed correlations between NK cell function and blood glucose concentrations. The purpose of the present study was to assess the NK cell activity and various metabolic parameters in people with type 2 diabetes, prediabetes and normal glucose tolerance. Materials and Methods A total of 49 participants were enrolled in the study. Anthropometric and biochemical parameters including age, sex, body mass index, smoking status, blood pressure, fasting plasma glucose, C‐peptide, insulin, glycated hemoglobin, total cholesterol, triglyceride, high‐density lipoprotein cholesterol and low‐density lipoprotein cholesterol were assessed. The 75 g oral glucose tolerance test was carried out for 2‐h postload glucose level. Homeostatic model assessment was calculated for insulin resistance and β‐cell function. NK cell activity was measured by detecting the circulating interferon‐gamma level secreted from NK cells. Results NK cell activity was lower in patients with type 2 diabetes (768.01 ± 650.35) compared with those with prediabetes (2,396.08 ± 653.76, P
Databáze: OpenAIRE
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