Presumed Assault or Accommodative Reactions Involved in Human Renal Transplantation
| Autor: | Kurt H. Stenzel, M. Fotino, A. Walle, R. R. Riggio, Manikkam Suthanthiran, Jhoong S. Cheigh |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Immunosuppression Therapy
Pathology medicine.medical_specialty business.industry Graft Survival chemical and pharmacologic phenomena General Medicine biochemical phenomena metabolism and nutrition Lymphocyte Activation Kidney Transplantation Models Biological Major Histocompatibility Complex Transplantation surgical procedures operative Immune system Nephrology Allograft rejection Immunology Humans bacteria Medicine Lymphocytes business Immune mechanisms |
| Zdroj: | Uremia Investigation. 8:245-249 |
| ISSN: | 0740-1353 |
| DOI: | 10.3109/08860228409115849 |
| Popis: | The concept that allograft loss is secondary to immune assault mechanisms and graft success is simply due to abatement of such graft-destructive forces represents a reductive viewpoint of the complex immune processes that are involved in allograft rejection. The immunologically dominated fate of renal allografts appears to rest on the delicate balance between mutually opposing graft-destructive and graft-protective immune mechanisms unleashed by the host following the perception of potent stimulatory signals originated by the allograft. Activated cells and their secretory products, responsible for the irrevocable destruction of the allograft and immune circuits that are pivotal to the generation of graft-adaptive immune responses, are being rapidly identified. |
| Databáze: | OpenAIRE |
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