Effect of Parietal Cell Vagotomy and Cholinergic Blockade on Gastrin Release in Man Induced by Gastrin-Releasing Peptide
| Autor: | Göran Lindstedt, Lars Olbe, L. Lundell, M. Sjövall |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
medicine.medical_specialty Pyrrolidines medicine.medical_treatment Biology digestive system Internal medicine Gastrin-releasing peptide Gastrins medicine Humans Secretion Vagotomy Proximal Gastric Gastrin Denervation Stomach digestive oral and skin physiology Gastroenterology Parasympatholytics Middle Aged Vagotomy medicine.anatomical_structure Endocrinology Gastrin-Releasing Peptide Duodenal Ulcer Duodenum Bombesin Female G cell Peptides hormones hormone substitutes and hormone antagonists |
| Zdroj: | Digestion. 46:114-120 |
| ISSN: | 1421-9867 0012-2823 |
| DOI: | 10.1159/000200340 |
| Popis: | The influence of cholinergic blockade as well as vagal denervation of the oxyntic gland mucosa on the gastrin response to gastrin-releasing peptide (GRP) have been studied in patients with duodenal ulcer disease. The gastric luminal content was neutralized during the experiments. GRP induced a substantial increase in gastrin levels with a peak response already after 15 min of infusion. Vagal denervation of the parietal cell area induced a significant increase in basal gastrin concentrations and a significant enhancement of the GRP response. Two different doses of benzilonium bromide were studied and neither influenced the basal concentrations of gastrin. A significantly increased gastrin response to GRP was, however, observed after administration of both a high and a very low dose of the anticholinergic drug. Our results delineate a vagal, noncholinergic inhibitory influence on the basal gastrin release. In addition a vagally dependent oxyntopyloric mechanism inhibits the gastrin release stimulated by GRP. This inhibitory mechanism may hypothetically be a cholinergic reflex mechanism. |
| Databáze: | OpenAIRE |
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