Anti-TNF-α Agent Tamarind Kunitz Trypsin Inhibitor Improves Lipid Profile of Wistar Rats Presenting Dyslipidemia and Diet-induced Obesity Regardless of PPAR-γ Induction
| Autor: | Izael de Sousa Costa, Vivian Nogueira Silbiger, Alexandre C. Serquiz, Ana Heloneida de Araújo Morais, Vanessa Cristina Oliveira de Lima, Anna Beatriz Santana Luz, Fernando Vagner Lobo Ladd, Raul Hernandes Bortolin, Elizeu Antunes dos Santos, Bruna Leal Lima Maciel, Fabiana Maria Coimbra de Carvalho |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Blood Glucose
Male 0301 basic medicine medicine.medical_specialty Trypsin inhibitor Adipose tissue 030209 endocrinology & metabolism lcsh:TX341-641 VLDL Diet High-Fat Article Random Allocation 03 medical and health sciences 0302 clinical medicine Internal medicine Glycemic load Tamarindus Animals Medicine Tamarindus indica L Obesity Rats Wistar triglycerides Dyslipidemias Plant Proteins Nutrition and Dietetics medicine.diagnostic_test Tumor Necrosis Factor-alpha business.industry medicine.disease Lipids Rats PPAR gamma 030104 developmental biology Glycemic index Endocrinology Gene Expression Regulation inflammation medicine.symptom Peptides business Lipid profile Weight gain lcsh:Nutrition. Foods and food supply Dyslipidemia Food Science |
| Zdroj: | Nutrients, Vol 11, Iss 3, p 512 (2019) Nutrients Volume 11 Issue 3 |
| ISSN: | 2072-6643 |
| Popis: | The increasing prevalence of obesity and, consequently, chronic inflammation and its complications has increased the search for new treatment methods. The effect of the purified tamarind seed trypsin inhibitor (TTIp) on metabolic alterations in Wistar rats with obesity and dyslipidemia was evaluated. Three groups of animals with obesity and dyslipidemia were formed, consuming a high glycemic index and glycemic load (HGLI) diet, for 10 days: Obese/HGLI diet Obese/standard diet Obese/HGLI diet + TTIp (730 &mu g/kg) and one eutrophic group of animals was fed a standard diet. Rats were evaluated daily for food intake and weight gain. On the 11th day, animals were anesthetized and sacrificed for blood and visceral adipose tissue collection. TTIp treated animals presented significantly lower food intake than the untreated group (p = 0.0065), TG (76.20 ± 18.73 mg/dL) and VLDL-C (15.24 ± 3.75 mg/dL). Plasma concentrations and TNF-&alpha mRNA expression in visceral adipose tissue also decreased in obese animals treated with TTIp (p < 0.05 and p = 0.025, respectively) with a negative immunostaining. We conclude that TTIp presented anti-TNF-&alpha activity and an improved lipid profile of Wistar rats with dyslipidemia and obesity induced by a high glycemic index and load diet regardless of PPAR-&gamma induction. |
| Databáze: | OpenAIRE |
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