Effects of oral florfenicol on intestinal structure, function and microbiota in mice
Autor: | Weiqi Shen, Shiyu Yun, Jia Chen, Lan Yang, Zhibian Duan, Wang Zhuo, Shuang Wen, Xin Zhang, Dongdong Zhao, Guo Yurong, Sun Yaogui, Haiping Wu |
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Rok vydání: | 2019 |
Předmět: |
Florfenicol
Male medicine.medical_specialty medicine.drug_class Antibiotics Crypt Administration Oral Firmicutes Occludin digestive system Biochemistry Microbiology Jejunum 03 medical and health sciences chemistry.chemical_compound Mice Random Allocation Immune system Oral administration Lactobacillus Internal medicine Genetics medicine Animals Intestinal Mucosa Molecular Biology 030304 developmental biology Thiamphenicol 0303 health sciences biology 030306 microbiology business.industry General Medicine biology.organism_classification Anti-Bacterial Agents Gastrointestinal Microbiome Interleukin-10 medicine.anatomical_structure Endocrinology chemistry Gene Expression Regulation business |
Zdroj: | Archives of microbiology. 202(1) |
ISSN: | 1432-072X |
Popis: | Many kinds of antibiotics have effects on intestinal structure and function. In the current experimental study, we evaluate the effect of oral florfenicol on intestinal barrier in mice. Thirty adult male mice were randomly divided into two groups, the group none (N) and the group florfenicol (F), the mice in group F were orally administered florfenicol 100 mg/kg body weight (BW) for 7 days. At day 8, mice were euthanized and sampled for the analysis of alterations in genes and proteins from jejunum, jejunum morphology and microbiota analysis. Administration of florfenicol caused higher liver index (P |
Databáze: | OpenAIRE |
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