Effects of oral florfenicol on intestinal structure, function and microbiota in mice

Autor: Weiqi Shen, Shiyu Yun, Jia Chen, Lan Yang, Zhibian Duan, Wang Zhuo, Shuang Wen, Xin Zhang, Dongdong Zhao, Guo Yurong, Sun Yaogui, Haiping Wu
Rok vydání: 2019
Předmět:
Zdroj: Archives of microbiology. 202(1)
ISSN: 1432-072X
Popis: Many kinds of antibiotics have effects on intestinal structure and function. In the current experimental study, we evaluate the effect of oral florfenicol on intestinal barrier in mice. Thirty adult male mice were randomly divided into two groups, the group none (N) and the group florfenicol (F), the mice in group F were orally administered florfenicol 100 mg/kg body weight (BW) for 7 days. At day 8, mice were euthanized and sampled for the analysis of alterations in genes and proteins from jejunum, jejunum morphology and microbiota analysis. Administration of florfenicol caused higher liver index (P
Databáze: OpenAIRE