Nerve growth factor-induced neuronal differentiation is accompanied by differential splicing of beta-amyloid precursor mRNAs in the PC12 cell line
| Autor: | Carthage J. Smith, Philippe Brachet, Didier Wion |
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| Rok vydání: | 1991 |
| Předmět: |
Transcription
Genetic RNA Splicing Molecular Sequence Data PC12 cell line Biology PC12 Cells Cellular and Molecular Neuroscience chemistry.chemical_compound Amyloid beta-Protein Precursor Neurotrophic factors Gene expression Animals Northern blot Nerve Growth Factors RNA Messenger Molecular Biology Neurons Base Sequence Alternative splicing Cell Differentiation Molecular biology Nerve growth factor nervous system chemistry Oligodeoxyribonucleotides Cell culture RNA splicing |
| Zdroj: | Brain research. Molecular brain research. 10(4) |
| ISSN: | 0169-328X |
| Popis: | The effect of the neurotrophic factor nerve growth factor (NGF) on the expression of the beta-amyloid gene has been studied in the clonal nerve cell line PC12. The neuronal differentiation of PC12 cells in the presence of NGF was accompanied by a shift in the ratio of beta-amyloid precursor protein (APP) transcripts. In particular there was reduced expression of the transcript coding for the longest precursor form (APP770) and a concomitant increase in the shortest (APP695) transcript following NGF treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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