Interactions between salicylic acid and pyridyl-3-methanol: anti-inflammatory and teratogenic effects
| Autor: | Eva Cekanova, Knut Larsson, E. Mörck, G. Åberg |
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| Rok vydání: | 1974 |
| Předmět: |
Male
Membrane permeability medicine.drug_class Phosphatase Acid Phosphatase Pharmacology Toxicology Anti-inflammatory chemistry.chemical_compound Mice Pregnancy medicine Animals Edema Drug Interactions Embryo Implantation Fetal Death Glucuronidase Inflammation Methanol Cell Membrane Nicotinic Acids Abnormalities Drug-Induced Drug Synergism Esters Teratology Salicylates Stimulation Chemical Hindlimb Rats Nicotinic agonist Membrane Biochemistry chemistry Female Lysosomes Salicylic acid |
| Zdroj: | Acta pharmacologica et toxicologica. 35(2) |
| ISSN: | 0001-6683 |
| Popis: | Anti-inflammatory and teratogenic effects of nicotinic acid, pyridyl-3-methanol and salicylic acid were studied. Tests were also performed on mixtures of salicylic acid and pyridyl-3-methanol and on an ester of pyridyl-3-methanol and salicylic acid (S-2063). Anti-inflammatory effects were studied on carrageenin-in-duced rat paw oedema and stabilizing effects were studied on rat liver lysosomes. Teratological studies were carried out on NMRI mice. Nicotinic acid was found to be very potent in the anti-inflammatory test and in stabilizing rat liver lysosomes. Pyridyl-3-methanol had less marked anti-inflammatory effects and had no significant stabilizing effect on the lysosomes. No foetal damage was caused. Salicylic acid had anti-inflammatory effects that were even less marked than those of pyridyl-3-metha-nol, but had slight stabilizing effects on the lysosomal membranes. Salicylate-induced skeletal malformations were obtained after treatment in early organogenesis. Given during late pregnancy a high incidence of foetal death and premature birth was observed. S-2063 had anti-inflammatory effects that were approximately the same as that of an equimolar mixture of salicylic acid and pyridyl-3-methanol. S-2063 caused a decreased membrane permeability of the lysosomal membranes for β-glu-curonidase but not for acid phosphatases. The teratogenic effect was not much increased as could be expected from the pronounced anti-inflammatory effect of S-2063. |
| Databáze: | OpenAIRE |
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