Propofol-Induced Vasodilation in Human Internal Mammary Artery: Role of Potassium Channels
| Autor: | Muhammed Fatih Dogan, Murat Kurtoglu, Seyfullah Oktay Arslan, Ali Parlar, Oguzhan Yildiz |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Potassium Channels Potassium chemistry.chemical_element Vasodilation 030204 cardiovascular system & hematology Pharmacology Calcium Glibenclamide 03 medical and health sciences Organ Culture Techniques 0302 clinical medicine 030202 anesthesiology Humans Medicine Coronary Artery Bypass Mammary Arteries Propofol Phenylephrine Aged Aged 80 and over Dose-Response Relationship Drug business.industry Middle Aged Iberiotoxin Potassium channel Anesthesiology and Pain Medicine chemistry Female Cardiology and Cardiovascular Medicine business Anesthetics Intravenous medicine.drug |
| Zdroj: | Journal of Cardiothoracic and Vascular Anesthesia. 33:2183-2191 |
| ISSN: | 1053-0770 |
| DOI: | 10.1053/j.jvca.2018.12.015 |
| Popis: | The aim of this study was to investigate the vascular effects and mechanisms of propofol in the human internal mammary artery (IMA).In vitro experimental study.The study was conducted in the research laboratory of a pharmacology department.IMA segments were obtained from 52 patients undergoing coronary artery bypass surgery.The IMA rings were suspended in isolated organ baths, and the changes in the tension were isometrically recorded. The antagonistic effect of propofol (1 μM, 10 μM, and 100 μM) on contractions induced by potassium chloride (45 mM), phenylephrine (1 μM), 5-hydroxytryptamine (30 μM), and calcium chloride (10 μM-10 mM) was investigated. The relaxations induced by propofol also were tested in the presence of the nitric oxide synthase inhibitor, nitro-L-arginine methyl ester (100 mM); the cyclooxygenase inhibitor, indomethacin (10 mM); and the potassium ion channel inhibitors, tetraethylammonium (1 mM), iberiotoxin (20 nM), glibenclamide (10 µM), 4-aminopyridine (1 mM), and barium chloride (30 µM).Propofol caused a significant concentration-dependent vasorelaxation, which was endothelium independent. It inhibited the contractions induced by potassium chloride, phenylephrine, 5-hydroxytryptamine, and calcium chloride (p0.001), but it did not affect the basal tension. Propofol-induced relaxation was significantly inhibited by iberiotoxin and tetraethylammonium (p0.001); however, it was not affected by 4-aminopyridine, glibenclamide, and barium chloride.This study clearly reveals that propofol relaxes the IMA, and propofol-induced vasodilation may be related to large conductance calcium ion-activated potassium ion channel activation. Propofol use in coronary artery bypass surgery can be valuable via its favorable vasodilator effect to overcome perioperative vasospasm of IMA. |
| Databáze: | OpenAIRE |
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