Effects of Bone Marrow Multipotent Mesenchymal Stromal Cells and Their Secretion Products on the Cellular Composition of the Thymus and Spleen of Female Wistar Rats with Experimental Chronic Inflammation of the Internal Genitals
Autor: | Vladimir I. Konenkov, O. B. Gritsyk, T. I. Dergacheva, M. V. Tenditnik, A. V. Shurlygina, E. V. Mel’nikova, O. V. Poveshchenko |
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Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Stromal cell T-Lymphocytes Multipotent Mesenchymal Stromal Cells Bone Marrow Cells Spleen Inflammation Thymus Gland Mesenchymal Stem Cell Transplantation General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine medicine Animals Secretion Lymphocyte Count Rats Wistar Vaginitis Cells Cultured Cellular composition Chemistry Mesenchymal Stem Cells General Medicine 030104 developmental biology medicine.anatomical_structure Female Bone marrow medicine.symptom 030217 neurology & neurosurgery |
Zdroj: | Bulletin of Experimental Biology and Medicine. 164:75-79 |
ISSN: | 1573-8221 0007-4888 |
Popis: | The effects of bone marrow multipotent mesenchymal stromal cells and their secretion products on the subpopulation composition of thymic and splenic lymphocytes were studied in female Wistar rats with experimental chronic inflammatory process in the internal genitals. Stromal cells and medium conditioned by these cells in different administration routes (intravenous or lymphotropic injection) produces different modulating effect on blood leukocyte count and on subpopulation composition of the splenic and thymic lymphocytes. The most manifest anti-inflammatory effect was observed after lymphotropic injection of multipotent mesenchymal stromal cells creating a high concentration and long persistence of the factors produced by these cells in the focus of inflammation. |
Databáze: | OpenAIRE |
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