Employing ATP as a New Adjuvant Promotes the Induction of Robust Antitumor Cellular Immunity by a PLGA Nanoparticle Vaccine

Autor:	Jinrong He, Xu Yang, Liangqun Hua, Yongjun Chen, Weiwei Huang, Chao Ye, Hongmei Bai, Mingcui Yuan, Zhongqian Yang, Fulan Gao, Sijin Li, Yanbing Ma, Qishu Zhang, Wenjia Sun, Weiran Li
Rok vydání:	2020
Předmět:	0301 basic medicine Cellular immunity Materials science Papillomavirus E7 Proteins medicine.medical_treatment Transplantation Heterologous Antigen-Presenting Cells Tumor vaccines Cancer Vaccines Mice 03 medical and health sciences chemistry.chemical_compound Adenosine Triphosphate 0302 clinical medicine Polylactic Acid-Polyglycolic Acid Copolymer Cell Line Tumor Neoplasms medicine Animals Humans General Materials Science Amino Acid Sequence Human papillomavirus Immunity Cellular virus diseases Dendritic Cells Mice Inbred C57BL Clinical trial PLGA 030104 developmental biology chemistry 030220 oncology & carcinogenesis Cancer research Nanoparticles Female Peptides Adjuvant
Zdroj:	ACS Applied Materials & Interfaces. 12:54399-54414
ISSN:	1944-8252 1944-8244
Popis:	Tumor vaccines based on synthetic human papillomavirus (HPV) oncoprotein E7 and/or E6 peptides have shown encouraging results in preclinical model studies and human clinical trials. However, the clinical efficacy may be limited by the disadvantages of vulnerability to enzymatic degradation and low immunogenicity of peptides. To further improve the potency of vaccine, we developed a poly(lactide
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ec4928004353803d3b0e2a740c6b3f https://doi.org/10.1021/acsami.0c15522 Zobrazit plný text záznamu