PET/MR in invasive ductal breast cancer: correlation between imaging markers and histological phenotype

Autor: Onofrio A. Catalano, Carlo Iannace, Alberto Signore, Marco Catalano, Mark Vangel, Gary Lloyd Horn, Andrea Soricelli, Constance D. Lehman, Umar Mahmood, Ciprian Catana, Marco Salvatore, Bruce R. Rosen, Maria Lepore, Angelo Luongo
Rok vydání: 2017
Předmět:
Cancer Research
Pathology
Receptor
ErbB-2
receptor
Receptor expression
receptors
multimodal imaging
carcinoma
030218 nuclear medicine & medical imaging
0302 clinical medicine
pet
middle aged
breast neoplasms
estrogen
Medicine
humans
skin and connective tissue diseases
radiopharmaceuticals
diffusion magnetic resonance imaging
medicine.diagnostic_test
adult
Carcinoma
Ductal
Breast
phenotypes
fluorodeoxyglucose f18
ductal
follow-up studies
aged
retrospective studies
female
Receptors
Estrogen
Oncology
Positron emission tomography
030220 oncology & carcinogenesis
young adult
Immunohistochemistry
Receptors
Progesterone
tumor
medicine.medical_specialty
phenotype
pet/mr
breast cancer
receptor expression
mr
adolescent
biomarkers
tumor
carcinoma
ductal
breast
ki-67 antigen
neoplasm staging
positron-emission tomography
prognosis
receptor
erbb-2
receptors
estrogen
receptors
progesterone
Standardized uptake value
progesterone
03 medical and health sciences
Breast cancer
Progesterone receptor
Biomarkers
Tumor
Effective diffusion coefficient
neoplasms
breast
business.industry
biomarkers
Magnetic resonance imaging
medicine.disease
body regions
Translational Therapeutics
business
erbb-2
Zdroj: British Journal of Cancer
ISSN: 1532-1827
0007-0920
DOI: 10.1038/bjc.2017.26
Popis: Background: Differences in genetics and receptor expression (phenotypes) of invasive ductal breast cancer (IDC) impact on prognosis and treatment response. Immunohistochemistry (IHC), the most used technique for IDC phenotyping, has some limitations including its invasiveness. We explored the possibility of contrast-enhanced positron emission tomography magnetic resonance (CE-FDG PET/MR) to discriminate IDC phenotypes. Methods: 21 IDC patients with IHC assessment of oestrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor-2 (HER2), and antigen Ki-67 (Ki67) underwent CE-FDG PET/MR. Magnetic resonance-perfusion biomarkers, apparent diffusion coefficient (ADC), and standard uptake value (SUV) were compared with IHC markers and phenotypes, using a Student's t-test and one-way ANOVA. Results: ER/PR− tumours demonstrated higher Kepmean and SUVmax than ER or PR+ tumours. HER2− tumours displayed higher ADCmean, Kepmean, and SUVmax than HER2+tumours. Only ADCmean discriminated Ki67⩽14% tumours (lower ADCmean) from Ki67>14% tumours. PET/MR biomarkers correlated with IHC phenotype in 13 out of 21 patients (62% P=0.001). Conclusions: Positron emission tomography magnetic resonance might non-invasively help discriminate IDC phenotypes, helping to optimise individual therapy options.
Databáze: OpenAIRE
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