Altered cerebral blood flow and cerebrovascular function after voluntary exercise in adult mice
| Autor: | John G. Sled, Lisa M. Gazdzinski, Adrienne Dorr, Jonathan Bishop, Bojana Stefanovic, Lindsay S. Cahill |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Histology Hippocampus Physical exercise Hippocampal formation 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Neuroimaging Physical Conditioning Animal Internal medicine medicine Animals medicine.diagnostic_test General Neuroscience Motor Cortex Magnetic resonance imaging Blood flow Magnetic Resonance Imaging Mice Inbred C57BL medicine.anatomical_structure Cerebral blood flow Cardiology Physical therapy Spin Labels Anatomy Psychology 030217 neurology & neurosurgery Motor cortex |
| Zdroj: | Brain Structure and Function. 222:3395-3405 |
| ISSN: | 1863-2661 1863-2653 |
| DOI: | 10.1007/s00429-017-1409-z |
| Popis: | The beneficial effects of physical exercise on brain health are well documented, yet how exercise modulates cerebrovascular function is not well understood. This study used continuous arterial spin labeling magnetic resonance imaging with a hypercapnic challenge to examine changes in cerebral blood flow and vascular function after voluntary exercise in healthy, adult mice. Thirty exercise mice and twenty-one control mice were imaged prior to the start of the exercise regime (at 12 weeks of age) and after 4 weeks of voluntary exercise. After the second in vivo imaging session, we performed high-resolution ex vivo anatomical brain imaging to correlate the structural brain changes with functional measures of flow and vascular reserve. We found that exercise resulted in increases in the normocapnic and hypercapnic blood flow in the hippocampus. Moreover, the change in normocapnic blood flow between pre-exercise and post-exercise was positively correlated to the hippocampal structure volume following exercise. There was no overall effect of voluntary exercise on blood flow in the motor cortex. Surprisingly, the hypercapnic hippocampal blood flow when measured prior to the start of exercise was predictive of subsequent exercise activity. Moreover, exercise was found to normalize this pre-existing difference in hypercapnic blood flow between mice. |
| Databáze: | OpenAIRE |
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