Causes and risk factors for infant mortality in Nunavut, Canada 1999–2011
| Autor: | Laura Arbour, Padma Surmala, Cheryl R. Greenberg, Sharon Edmunds-Potvin, Sorcha A. Collins, Laakkuluk Williamson Bathory, Geraldine Osborne |
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| Přispěvatelé: | University of Manitoba |
| Rok vydání: | 2012 |
| Předmět: |
Genetic Markers
Pediatrics medicine.medical_specialty Sudden infant death syndrome Population Nunavut Infant mortality Infections 03 medical and health sciences 0302 clinical medicine Risk Factors Cause of Death 030225 pediatrics medicine Humans Pediatrics Perinatology and Child Health 030212 general & internal medicine Inuit population education Aboriginal Retrospective Studies Cause of death High rate education.field_of_study Carnitine O-Palmitoyltransferase Carnitine palmitoyltransferase 1 deficiency CPT1A P479L variant business.industry Infant Care Infant Newborn lcsh:RJ1-570 Infant lcsh:Pediatrics 3. Good health Inuit Pediatrics Perinatology and Child Health Sudden unexpected death in infancy National average business Infant Premature Sudden Infant Death Research Article Demography |
| Zdroj: | BMC Pediatrics, Vol 12, Iss 1, p 190 (2012) BMC Pediatrics |
| ISSN: | 1471-2431 |
| DOI: | 10.1186/1471-2431-12-190 |
| Popis: | Background The northern territory Nunavut has Canada’s largest jurisdictional land mass with 33,322 inhabitants, of which 85% self-identify as Inuit. Nunavut has rates of infant mortality, postneonatal mortality and hospitalisation of infants for respiratory infections that greatly exceed those for the rest of Canada. The infant mortality rate in Nunavut is 3 times the national average, and twice that of the neighbouring territory, the Northwest Territories. Nunavut has the largest Inuit population in Canada, a population which has been identified as having high rates of Sudden Infant Death Syndrome (SIDS) and infant deaths due to infections. Methods To determine the causes and potential risk factors of infant mortality in Nunavut, we reviewed all infant deaths ( Results Sudden death in infancy (SIDS/SUDI; 48%) and infection (21%) were the leading causes of infant death, with rates significantly higher than for Canada (2003–2007). Of SIDS/SUDI cases with information on sleep position (n=42) and bed-sharing (n=47), 29 (69%) were sleeping non-supine and 33 (70%) were bed-sharing. Of those bed-sharing, 23 (70%) had two or more additional risk factors present, usually non-supine sleep position. CPT1A P479L homozygosity, which has been previously associated with infant mortality in Alaska Native and British Columbia First Nations populations, was associated with unexpected infant death (SIDS/SUDI, infection) throughout Nunavut (OR:3.43, 95% CI:1.30-11.47). Conclusion Unexpected infant deaths comprise the majority of infant deaths in Nunavut. Although the CPT1A P479L variant was associated with unexpected infant death in Nunavut as a whole, the association was less apparent when population stratification was considered. Strategies to promote safe sleep practices and further understand other potential risk factors for infant mortality (P479L variant, respiratory illness) are underway with local partners. |
| Databáze: | OpenAIRE |
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