Reduced effects of age on dopamine D2 receptor levels in physically active adults

Autor:	David H. Zald, Ronald L. Cowan, Scott F. Perkins, Nam T. Le, Gregory R. Samanez-Larkin, Linh C. Dang, Jaime J. Castrellon
Rok vydání:	2017
Předmět:	Adult Male 0301 basic medicine Aging medicine.medical_specialty Cognitive Neuroscience Physical activity Degeneration (medical) Striatum Article Midbrain Young Adult 03 medical and health sciences 0302 clinical medicine Dopamine Internal medicine Dopamine receptor D2 medicine Humans Exercise Aged Aged 80 and over Receptors Dopamine D2 Dopaminergic Receptors Dopamine D3 Brain Middle Aged Magnetic Resonance Imaging Cross-Sectional Studies 030104 developmental biology Endocrinology Neurology Fallypride Positron-Emission Tomography Benzamides Female Radiopharmaceuticals Psychology 030217 neurology & neurosurgery medicine.drug
Zdroj:	NeuroImage. 148:123-129
ISSN:	1053-8119
Popis:	Physical activity has been shown to ameliorate dopaminergic degeneration in non-human animal models. However, the effects of regular physical activity on normal age-related changes in dopamine function in humans are unknown. Here we present cross-sectional data from forty-four healthy human subjects between 23 and 80 years old, showing that typical age-related dopamine D2 receptor loss, assessed with PET [18F]fallypride, was significantly reduced in physically active adults compared to less active adults.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e9f738109e591ecc8202c6b4cc9d14 https://doi.org/10.1016/j.neuroimage.2017.01.018 Zobrazit plný text záznamu Full Text from ScienceDirect