Blood–brain barrier dysfunction occurring in mice infected with Angiostrongylus cantonensis
| Autor: | June-Der Lee, Li-Yu Tsai, Jiun-Jye Wang, Chuan-Min Yen, Chun-Hsiang Chen, Jen-Kuei Hsiao |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Veterinary (miscellaneous) Serum albumin Blood–brain barrier Leukocyte Count Mice chemistry.chemical_compound Cerebrospinal fluid Internal medicine medicine Animals Meningitis Angiostrongylus Serum Albumin Strongylida Infections Evans Blue biology CSF/serum albumin ratio Albumin Eosinophil biology.organism_classification Angiostrongylus cantonensis Eosinophils Mice Inbred C57BL Kinetics Infectious Diseases medicine.anatomical_structure Endocrinology chemistry Blood-Brain Barrier Insect Science Immunology Erythrocyte Count biology.protein Parasitology |
| Zdroj: | Acta Tropica. 97:204-211 |
| ISSN: | 0001-706X |
| Popis: | Several indices were used to assess whether blood-brain barrier (BBB) damage occurs in neurological disorders. Dysfunction of the BBB was surmised to be involved in the pathological changes of eosinophilic meningitis caused by the infection of Angiostrongylus cantonensis. The mean concentration of protein and albumin in the cerebrospinal fluid (CSF) of infected mice gradually increased from days 0 to 18 after infection and then rapidly increased 21 days after infection. The concentrations of protein and albumin in the CSF of infected mice 15 days after infection were all significantly higher than those in uninfected mice (all P-values at least |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect