Toxicity of naproxen sodium and its mixture with tramadol hydrochloride on fish early life stages
| Autor: | Pavla Sehonova, Emma Fiorino, Jana Blahova, Lucie Plhalova, Veronika Doubkova, Caterina Faggio, Miroslav Prokes, Frantisek Tichy, Zdenka Svobodova |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Naproxen Carps Environmental Engineering Health Toxicology and Mutagenesis Sodium chemistry.chemical_element Naproxen Sodium 010501 environmental sciences Pharmacology 01 natural sciences Cyprinus 03 medical and health sciences Common carp Cyprinus carpio Toxicity Tests medicine Animals Environmental Chemistry Tramadol LOEC 0105 earth and related environmental sciences Chromatography biology Surface waters Public Health Environmental and Occupational Health Cyprinus carpio LOEC Oxidative stress Surface waters Toxicity tests General Medicine General Chemistry biology.organism_classification Pollution Oxidative Stress 030104 developmental biology chemistry Larva Toxicity Tramadol Hydrochloride Water Pollutants Chemical medicine.drug |
| Zdroj: | Chemosphere. 188:414-423 |
| ISSN: | 0045-6535 |
| DOI: | 10.1016/j.chemosphere.2017.08.151 |
| Popis: | Pharmaceuticals occur in water bodies as a consequence of their incomplete removal during waste water treatment processes. The occurence of pharmaceuticals in surface waters as well as their possible impact on aquatic vertebrates have received considerable attention in recent years. However, there is still a lack of informations on the chronic effects of widely used drugs as well as their possible mixture toxicity on non-target aquatic vertebrates as well as their possible mixture toxicity. The aim of this study was to assess the effects of naproxen sodium on early life stages of fish and evaluate its mixture toxicity with tramadol hydrochloride, which was assessed in our earlier study as a single substance. Two embryo-larval toxicity tests with common carp (Cyprinus carpio) were performed according to the OECD guideline 210 (Fish, Early-life Stage Toxicity Test) in order to assess the subchronic toxicity of naproxen sodium and tramadol hydrochlorid-naproxen sodium mixture at the concentrations of 10; 50; 100 and 200 μg/L. These experiments were conducted for 32 days. The subchronic exposure to naproxen sodium and naproxen sodium and tramadol hydrochloride mixture had a strong effect on the early life stages of common carp. Hatching, developmental rate, morphology, histopathology and, in the case of the naproxen sodium and tramadol hydrochloride mixture, mortality were influenced. The bioindicators of oxidative stress were also influenced. The LOEC was determined at 10 μg/L for both naproxen sodium and naproxen sodium and tramadol hydrochloride mixture. |
| Databáze: | OpenAIRE |
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