Marine Sesquiterpenes for Plant Protection: Discovery of Laurene Sesquiterpenes and Their Derivatives as Novel Antiviral and Antiphytopathogenic Fungal Agents

Autor:	Xin Ding, Yubin Xu, Lili Yan, Lei Chen, Zujia Lu, Caiyan Ge, Xinyi Zhao, Ziwen Wang, Aidang Lu, Qingmin Wang
Rok vydání:	2022
Předmět:	Tobacco Mosaic Virus Structure-Activity Relationship Drug Design Fungi General Chemistry Pesticides General Agricultural and Biological Sciences Antiviral Agents Sesquiterpenes
Zdroj:	Journal of Agricultural and Food Chemistry. 70:6006-6014
ISSN:	1520-5118 0021-8561
DOI:	10.1021/acs.jafc.2c00664
Popis:	The unreasonable use or long-term use of a single variety of pesticide has led to drug resistance and made the pesticides ineffective. Therefore, the creation of new, efficient, and low-risk pesticides is imminent. Marine natural products play a vital role in serving as new lead compounds. In this work, we realized the efficient preparation of nine marine sesquiterpenes with the Stork-Danheiser reaction as the key step and designed and synthesized a series of their derivatives. The antiviral activity and antifungal activity research showed that these compounds exhibited good to excellent biological activities. Compounds
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e62c4272acdff46e1ce02fcd4ab681 https://doi.org/10.1021/acs.jafc.2c00664 Zobrazit plný text záznamu