The Emerging Role of Nutraceuticals in Cardiovascular Calcification: Evidence from Preclinical and Clinical Studies
| Autor: | Francesco Cinetto, Elisabetta Faggin, Carla Felice, Nicola Ferri, M. Rattazzi, Maria Giovanna Lupo, Maristella Donato |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Aortic valve
Vitamin K 030232 urology & nephrology Disease Review 030204 cardiovascular system & hematology Bioinformatics 03 medical and health sciences 0302 clinical medicine Nutraceutical Nutraceuticals Nutrition Vascular calcification Vascular Stiffness Cardiovascular calcification Risk Factors medicine Humans TX341-641 Pathological Nutritional deficiency nutraceuticals Nutrition and Dietetics business.industry Nutrition. Foods and food supply Malnutrition Aortic Valve Stenosis Arteries medicine.disease medicine.anatomical_structure nutrition Cardiovascular Diseases vascular calcification Aortic valve stenosis Aortic Valve Dietary Supplements business Food Science |
| Zdroj: | Nutrients, Vol 13, Iss 2603, p 2603 (2021) Nutrients |
| ISSN: | 2072-6643 |
| Popis: | Cardiovascular calcification is the ectopic deposition of calcium-phosphate crystals within the arterial wall and the aortic valve leaflets. This pathological process leads to increased vascular stiffness, reduced arterial elasticity, and aortic valve stenosis, increasing the risk of cardiovascular diseases. Although cardiovascular calcification is an increasing health care burden, to date no medical therapies have been approved for treating or preventing it. Considering the current lack of therapeutic strategies and the increasing prevalence of cardiovascular calcification, the investigation of some nutraceuticals to prevent this pathological condition has become prevalent in recent years. Recent preclinical and clinical studies evaluated the potential anti-calcific role of nutraceuticals (including magnesium, zinc, iron, vitamin K, and phytate) in the progression of vascular calcification, providing evidence for their dietary supplementation, especially in high-risk populations. The present review summarizes the current knowledge and latest advances for nutraceuticals with the most relevant preclinical and clinical data, including magnesium, zinc, iron, vitamin K, and phytate. Their supplementation might be recommended as a cost-effective strategy to avoid nutritional deficiency and to prevent or treat cardiovascular calcification. However, the optimal dose of nutraceuticals has not been identified and large interventional trials are warranted to support their protective effects on cardiovascular disease. |
| Databáze: | OpenAIRE |
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