Protective effect of Group B Streptococcus type-III polysaccharide conjugates against maternal colonization, ascending infection and neonatal transmission in rodent models

Autor:	Maria Rita Fontana, Monica Fabbrini, Eleonora Naimo, Silvia Maccari, Angela Spagnuolo, Bruno Galletti, Emiliano Chiarot, Alessandra Acquaviva, Paolo Ruggiero, Immaculada Margarit, Guido Grandi, Giuliano Bensi, Raffaella Cecchi, Elena Mori
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	0301 basic medicine lcsh:Medicine Group B Article 03 medical and health sciences Mice Streptococcal Infections medicine Animals Colonization Antibiotic prophylaxis lcsh:Science Pregnancy Multidisciplinary business.industry Transmission (medicine) Polysaccharides Bacterial Streptococcal Vaccines Vaccination lcsh:R medicine.disease Infectious Disease Transmission Vertical Rats Disease Models Animal 030104 developmental biology medicine.anatomical_structure Immunization Immunology Vagina Female lcsh:Q business
Zdroj:	Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018) Scientific Reports
ISSN:	2045-2322
DOI:	10.1038/s41598-018-20609-5
Popis:	Group B Streptococcus (GBS) is a normal inhabitant of recto-vaginal mucosae in up to 30% of healthy women. Colonization is a major risk factor for perinatal infection which can lead to severe complications such as stillbirth and neonatal invasive disease. Intra-partum antibiotic prophylaxis in colonized women is a safe and cost-effective preventive measure against early-onset disease in the first days of life, but has no effect on late-onset manifestations or on early maternal infection. Maternal immunization with capsular polysaccharide-based vaccines shows promise for the prevention of both early-onset and late-onset neonatal infections, although ability to prevent maternal colonization and ascending infection has been less studied. Here we investigated the effect of a GBS glycoconjugate vaccine since the very early stage of maternal GBS acquisition to neonatal outcome by rodent models of vaginal colonization and ascending infection. Immunization of female mice and rats with a type III glycoconjugate reduced vaginal colonization, infection of chorioamniotic/ placental membranes and bacterial transmission to fetuses and pups. Type III specific antibodies were detected in the blood and vagina of vaccinated mothers and their offspring. The obtained data support a potential preventive effect of GBS glycoconjugate vaccines during the different stages of pregnancy.
Databáze:	OpenAIRE
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