Nanostructured mixed Ni/Pt hydroxides electrodes for BIA-amperometry determination of hydralazine
| Autor: | Nathália F. B. Azeredo, Pamela O. Rossini, Koiti Araki, Josué M. Gonçalves, Lúcio Angnes, Geovanne L. de Assis |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Materials science
medicine.diagnostic_test General Chemical Engineering chemistry.chemical_element 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology Tin oxide 01 natural sciences Amperometry 0104 chemical sciences chemistry.chemical_compound Nickel chemistry Spectrophotometry Electrode AMPEROMETRIA medicine Hydroxide 0210 nano-technology Platinum Voltammetry Nuclear chemistry |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1876-1070 |
| Popis: | A fluorine doped tin oxide (FTO) coated glass modified with mixed nickel/platinum hydroxide nanoparticles (α-Ni0.98Pt0.02(OH)2) was utilized as BIA amperometric sensor for fast determination of hydralazine in pharmaceutical formulations. The new electrode material was characterized by X-ray diffraction (XRD), thermal analysis (TG-DTA), transmission electron microscopy (TEM) and voltammetry, exhibiting high conductivity and enhanced activity compared to the FTO electrode without modification. The α-Ni0.98Pt0.02(OH)2 electrode associated with batch injection analysis (BIA) showed good amperometric response to hydralazine, attaining detection and quantification limits of 5.93 × 10−6 and 2.0 × 10−5 mol/L, respectively, besides elevated analytical frequency (240 samples/h). The amount of hydralazine in real pharmaceutical samples were analyzed by BIA/amperometry and UV–Vis spectrophotometry, the method recommended by the United States Pharmacopeia, giving comparable results. In fact, both methods presented very good concordance (difference of 0.8%) indicating that the BIA method associated with the features of α-Ni0.98Pt0.02(OH)2 electrode is thus well-suited for electroanalytical purposes, and can be employed for determination of hydralazine in pharmaceuticals. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect