Determination of chromium in urine by stable isotope dilution gas chromatography/mass spectrometry using lithium bis(trifluoroethyl)dithiocarbamate as a chelating agent
| Autor: | Michael Kinter, David A. Herold, John Savory, Michael R. Wills, Suresh K. Aggarwal |
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| Rok vydání: | 1990 |
| Předmět: |
Chromium
chemistry.chemical_classification Radioisotope Dilution Technique Chromatography Chemistry Stable isotope ratio chemistry.chemical_element Isotope dilution Mass spectrometry Gas Chromatography-Mass Spectrometry Analytical Chemistry Thiocarbamates Humans Selected ion monitoring Gas chromatography Gas chromatography–mass spectrometry Dithiocarbamate Chelating Agents |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1520-6882 0003-2700 |
| DOI: | 10.1021/ac00201a005 |
| Popis: | An isotope dilution gas chromatography/mass spectrometry method using lithium bis(trifluoroethyl)dithiocarbamate as a chelating agent is described for the determination of chromium in urine. A wet digestion procedure with HNO3-H2O2 is used for oxidizing the organic matter associated with urine samples. The isotope ratios are measured by selected ion monitoring in a general-purpose mass spectrometer using a 10-m fused silica capillary column. Memory effect, in sequential analyses of samples with different isotope ratios, was evaluated by preparing a series of synthetic mixtures and was found to be negligible. The accuracy of the method was verified by quantitation of chromium in the NIST freeze-dried urine reference material, SRM-2670, with a recommended chromium concentration of 13 micrograms/L in the normal level and certified chromium concentration of 85 +/- 6 micrograms/L in the elevated level. |
| Databáze: | OpenAIRE |
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