Experience with therapeutic drug monitoring of three antifungal agents using an LC-MS/MS method in routine clinical practice
| Autor: | Kyung-Hoon Lee, Hye In Woo, Jongwon Oh, Sun Joo Yoon, Soo-Youn Lee |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Antifungal 030213 general clinical medicine Posaconazole Antifungal Agents medicine.drug_class Itraconazole Clinical Biochemistry 030204 cardiovascular system & hematology Pharmacology Biochemistry 03 medical and health sciences 0302 clinical medicine Therapeutic index Tandem Mass Spectrometry Lc ms ms medicine Humans Protein precipitation Aged Voriconazole medicine.diagnostic_test business.industry Biochemistry (medical) General Medicine Middle Aged Therapeutic drug monitoring Female Drug Monitoring business Chromatography Liquid medicine.drug |
| Zdroj: | Clinical Biochemistry. 70:14-17 |
| ISSN: | 0009-9120 |
| Popis: | Therapeutic drug monitoring (TDM) of voriconazole, itraconazole, and posaconazole is a useful tool for treatment of fungal infections. We validated a simple and reliable LC-MS/MS method using simple protein precipitation for simultaneous determination of voriconazole, itraconazole, and posaconazole. The linearity, accuracy, precision, carryover, and matrix effects were validated. Total sample preparation time was |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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