Trends and geographic inequalities in the prevalence of Down syndrome in Europe, 1980-1999
| Autor: | H. Jordan, D. Lillis, C. De Vigan, Maria Loane, Blanca Gener, Ester Garne, Fabrizio Bianchi, Claude Stoll, H. E. K. De Walle, Annette Queisser-Luft, Maria Feijoo, Martin Haeusler, Marie-Claude Addor, David Tucker, Helen Dolk |
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| Přispěvatelé: | Reproductive Origins of Adult Health and Disease (ROAHD) |
| Rok vydání: | 2005 |
| Předmět: |
Adult
Pediatrics medicine.medical_specialty Down syndrome Inequality Epidemiology media_common.quotation_subject Population Prenatal diagnosis DIAGNOSIS Prevalence termination of pregnancy Humans Medicine media_common.cataloged_instance Registries European union education AGE-SPECIFIC RISK media_common Pregnancy education.field_of_study prenatal diagnosis business.industry Public Health Environmental and Occupational Health medicine.disease Europe Prenatal screening Female Down Syndrome Live birth business Maternal Age Demography |
| Zdroj: | ResearcherID Scopus-Elsevier Revue d epidemiologie et de sante publique, 53, 2S87-2S95 Dolk, H, Loane, M, Garne, E, De Walle, H, Queisser-Luft, A, De Vigan, C, Addor, M C, Gener, B, Haeusler, M, Jordan, H, Tucker, D, Stoll, C, Feijoo, M, Lillis, D & Bianchi, F 2005, ' Trends and geographic inequalities in the prevalence of Down syndrome in Europe, 1980-1999 ', Revue d'Epidemiologie et de Sante Publique, vol. 53, no. 2, pp. 87-95 . |
| ISSN: | 0398-7620 |
| Popis: | Background EUROCAT is a network of population-based registries for the epidemiologic surveillance of congenital anomalies covering approximately one quarter of births in the European Union. Down syndrome constitutes approximately 8% of cases of registered congenital anomaly in Europe, with over 7 000 affected pregnancies in the 15 current member states of the European Union each year. In this paper, we aim to examine trends in the live birth prevalence of Down syndrome in Europe in the light of trends in maternal age and in prenatal diagnosis. Methods Descriptive analysis of data from 24 EUROCAT registries, covering 8.3 million births 1980-99. Cases include live births, stillbirths and terminations of pregnancy following prenatal diagnosis. Results Since 1980, the proportion of births to mothers of 35 years of age and over has risen quite dramatically from 8 to 14% for the European Union as a whole, with steeper rises in some regions. By 1995-1999, the proportion of “older” mothers varied between regions from 10% to 25%, and the total prevalence (including terminations of pregnancy) of Down syndrome varied from 1 to 3 per 1 000 births. Some European regions have shown a more than twofold increase in total prevalence of Down syndrome since 1980. The proportion of cases of Down syndrome which were prenatally diagnosed followed by termination of pregnancy in 1995-1999 varied from 0% in the three regions of Ireland and Malta where termination of pregnancy is illegal, to less than 50% in 14 further regions, to 77% in Paris. The extent to which terminations of pregnancy were concentrated among older mothers varied between regions. The live birth prevalence has since 1980 increasingly diverged from the rising total prevalence, in some areas remaining approximately stable, in others decreasing over time. Conclusion The rise in average maternal age in Europe has brought with it an increase in the number of pregnancies affected by Down syndrome. The widespread practice of prenatal screening and termination of pregnancy has in most of the regions covered by EUROCAT counteracted the effect of maternal age in its effect on live birth prevalence. Under the joint influences of maternal age and prenatal screening the pattern of geographic inequalities in Down syndrome live birth prevalence in Europe has also been changed. |
| Databáze: | OpenAIRE |
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