Roles of hippocampal N-methyl-D-aspartate receptors and calcium/calmodulin-dependent protein kinase II in amphetamine-produced conditioned place preference in rats
| Autor: | Lifa Yu, Shojiro Sakurai, Soon-Eng Tan |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Benzylamines Immunoblotting chemistry.chemical_element Calcium Hippocampal formation Motor Activity Hippocampus Receptors N-Methyl-D-Aspartate Internal medicine Ca2+/calmodulin-dependent protein kinase medicine Excitatory Amino Acid Agonists Animals Receptors AMPA Rats Wistar Amphetamine Pharmacology Sulfonamides Behavior Animal musculoskeletal neural and ocular physiology Glutamate receptor Protein kinase II Conditioned place preference Rats Psychiatry and Mental health Endocrinology nervous system chemistry Biochemistry 2-Amino-5-phosphonovalerate Cycloserine Calcium-Calmodulin-Dependent Protein Kinases NMDA receptor Conditioning Operant Central Nervous System Stimulants Calcium-Calmodulin-Dependent Protein Kinase Type 2 medicine.drug |
| Zdroj: | Behavioural pharmacology. 18(5-6) |
| ISSN: | 0955-8810 |
| Popis: | This study investigates the roles of hippocampal N-methyl-D-aspartate (NMDA) glutamate receptors and CaMKII (calcium/calmodulin-dependent protein kinase II) in amphetamine-produced conditioned place preference (AMPH-CPP) in rats. An earlier report showed that AMPH-CPP resulted in the enhancement of hippocampal CaMKII activity. In this study, AMPH-CPP significantly increased hippocampal GluR1 receptors, though AMPH-CPP was impaired by either blockade of NMDA receptors (AP5) or inhibition of CaMKII (KN-93) during conditioning. These treatments also impaired CPP if administered before testing, but CPP recovered during the next testing session. Therefore, these treatments had no effect on the extinction of CPP. If the conditioned rats were, however, reexposed to AMPH-CPP after a hippocampal-infusion of AP5 or KN-93, the extinction of the original CPP was greater than that seen in the controls. The hippocampal-infusion of D-cycloserine before CPP testing enhanced the extinction of CPP. These results, taken together, indicate that NMDA receptor activation and CaMKII activity are essential for the AMPH-CPP. AMPH-CPP reexposure is similar to the memory reconsolidation process, being disrupted by either a blockade of the NMDA receptor or an inhibition of CaMKII. Furthermore, the extinction of CPP resembles new learning, which is an active process and is facilitated by a partial NMDA agonist. |
| Databáze: | OpenAIRE |
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