Intraocular pressure elevation after subtenon triamcinolone acetonide injection; Multicentre retrospective cohort study in Japan

Autor: Tomohiro Ikeda, Yoshihiro Takamura, Nahoko Ogata, Chihiro Yamanaka, Hiroki Nishikawa, Rie Ogihara, Masahiko Sugimoto, Mineo Kondo, Hiroto Ishikawa, Yoshinori Mitamura, Yuki Maeda, Shigehiko Kitano, Fumi Gomi, Takamasa Kinoshita, Miho Shimizu
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Intraocular pressure
Eye Diseases
genetic structures
Epidemiology
Glaucoma
Triamcinolone Acetonide
Cohort Studies
0302 clinical medicine
Japan
Medicine and Health Sciences
Medicine
030212 general & internal medicine
Multidisciplinary
Organic Compounds
Incidence (epidemiology)
Ophthalmic Procedures
Middle Aged
Chemistry
Physical Sciences
Steroids
Female
Anatomy
Uveitis
Cohort study
Research Article
medicine.medical_specialty
Endpoint Determination
Science
Surgical and Invasive Medical Procedures
Injections
03 medical and health sciences
Ocular System
Ophthalmology
Humans
Risk factor
Intraocular Pressure
Retrospective Studies
business.industry
Organic Chemistry
Chemical Compounds
Biology and Life Sciences
Retrospective cohort study
medicine.disease
eye diseases
Medical Risk Factors
030221 ophthalmology & optometry
Eyes
sense organs
business
Head
Zdroj: PLoS ONE, Vol 14, Iss 12, p e0226118 (2019)
PLoS ONE
ISSN: 1932-6203
Popis: Purpose To evaluate real-world evidence for intraocular pressure (IOP) elevation after subtenon triamcinolone acetonide injection (STTA) in 1252 Japanese patients (1406 eyes) in the Japan Clinical REtina STudy group (J-CREST). Methods This was a multicentre retrospective study of the medical records of 1252 patients (676 men (758 eyes); mean age: 63.8 ± 12.9 years) who received STTA in participating centres between April 2013 and July 2017. Results IOP elevation was observed in 206 eyes (14.7%) and IOP increase ≥ 6 mmHg was found in 328 eyes (23.3%). In total, 106 eyes (7.5%) needed medication and two eyes (0.14%) needed surgical procedures. Younger age, higher baseline IOP, and steroid dose were risk factors associated with IOP elevation. Risk factors associated with IOP increase ≥ 6 mmHg were younger age, lower baseline IOP, steroid dose, and higher incidences of diabetic macular oedema (DME) and uveitis. In contrast, with steroid dose fixed at 20 mg, a lower incidence of DME was a risk factor for increased IOP, suggesting that STTA had dose-dependent effects on IOP increase, especially in patients with DME. Conclusion Our real-world evidence from a large sample of Japanese patients who received STTA showed that the incidence of IOP elevation after STTA was 14.7%, and was associated with younger age, higher baseline IOP, and steroid dose. Thus, IOP should be monitored, especially in patients with younger age, higher baseline IOP, and higher incidences of DME and uveitis.
Databáze: OpenAIRE
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