Role of human papilloma virus-16 in the pathogenesis of oral lichen planus – an immunohistochemical study
| Autor: | Chetan A Pol, Suvarna K Ghige, Suchitra R Gosavi |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Disease Antibodies Viral Virus Pathogenesis Young Adult stomatognathic system medicine Humans Coloring Agents General Dentistry Retrospective Studies Cell Nucleus Human papillomavirus 16 biology business.industry Papillomavirus Infections Mouth Mucosa Middle Aged medicine.disease Immunohistochemistry stomatognathic diseases Exact test Case-Control Studies biology.protein Papilloma Female Oral lichen planus Sceintific Research Report Antibody business Lichen Planus Oral |
| Zdroj: | Int Dent J |
| ISSN: | 0020-6539 |
| Popis: | Background Oral lichen planus (OLP) is a common chronic inflammatory immune-mediated disease with an aetiopathogenesis associated with cell-mediated immunological dysfunction. It is possible that oral mucosal viral infections, including human papilloma virus-16 (HPV-16) infection, may have a causative role in OLP pathogenesis. Aim To assess the prevalence of HPV-16 in histopathologically diagnosed specimens of OLP and to evaluate whether any clinical features (such as the localisation of specimens) or the age or gender of patients, are correlated with the presence of this virus. Materials and methods This study was conducted on 30 specimens with a histopathological diagnosis of OLP, using the immunohistochemical marker HPV-16. Thirty normal oral mucosa specimens were also included as controls. Brown nuclear staining was accepted as positive for the HPV-16 antibody. The results were analysed using Fisher's exact test. P values |
| Databáze: | OpenAIRE |
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