A Liver-X-Receptor Ligand, T0901317, Attenuates IgE Production and Airway Remodeling in Chronic Asthma Model of Mice

Autor: Wei Gu, Yan Tan, Xiantao Xu, Shan Mao, Surong Fang, Ying Shi
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Pulmonology
Hydrocarbons
Fluorinated
Physiology
lcsh:Medicine
Antigen Processing and Recognition
Immunoglobulin E
Ligands
Biochemistry
Mice
Animal Cells
Immune Physiology
Medicine and Health Sciences
lcsh:Science
Lung
Liver X Receptors
Mice
Inbred BALB C
Sulfonamides
Multidisciplinary
Immune System Proteins
biology
medicine.diagnostic_test
respiratory system
Orphan Nuclear Receptors
medicine.anatomical_structure
Matrix Metalloproteinase 9
Airway Remodeling
lipids (amino acids
peptides
and proteins)
Female
Collagen
medicine.symptom
Cellular Types
Bronchoalveolar Lavage Fluid
Research Article
Agonist
Drug Research and Development
medicine.drug_class
Ovalbumin
Immune Cells
Immunology
Antigen-Presenting Cells
Inflammation
Transforming Growth Factor beta1
medicine
Animals
Antigens
Liver X receptor
Pharmacology
business.industry
lcsh:R
Biology and Life Sciences
Proteins
Muscle
Smooth
Cell Biology
Allergens
Asthma
respiratory tract diseases
Bronchoalveolar lavage
biology.protein
lcsh:Q
Clinical Immunology
Clinical Medicine
business
Airway
Zdroj: PLoS ONE
PLoS ONE, Vol 9, Iss 3, p e92668 (2014)
ISSN: 1932-6203
Popis: The liver-X-receptors have shown anti-inflammatory ability in several animal models of respiratory disease. Our purpose is to investigate the effect of LXR ligand in allergen-induced airway remodeling in mice. Ovalbumin-sensitized mice were chronically challenged with aerosolized ovalbumin for 8 weeks. Some mice were administered a LXR agonist, T0901317 (12.5, 25, 50 mg/kg bodyweight) before challenge. Then mice were evaluated for airway inflammation, airway hyperresponsiveness and airway remodeling. T0901317 failed to attenuate the inflammatory cells and Th2 cytokines in bronchoalveolar lavage fluid. But the application of T0901317 reduced the thickness of airway smooth muscle and the collagen deposition. Meanwhile, T0901317 treatment evidently abolished the high level of OVA-specific IgE, TGF-β1 and MMP-9 in lung. So LXRs may attenuate the progressing of airway remodeling, providing a potential treatment of asthma.
Databáze: OpenAIRE
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