Beneficial Effects of Tibolone on Blood Pressure and Liver Redox Status in Ovariectomized Rats With Renovascular Hypertension
| Autor: | Eduardo Hideo Gilglioni, Monique Cristine de Oliveira, Ana Julia dos Reis Buzzo, Lilian Brites Campos, Célia Regina Ambiel, Emy Luzia Ishii-Iwamoto, Rosângela Fernandes Garcia, Clairce Luzia Salgueiro-Pagadigorria |
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| Rok vydání: | 2012 |
| Předmět: |
Aging
medicine.medical_specialty Mean arterial pressure Norpregnenes Ovariectomy Blood Pressure Tibolone Renovascular hypertension chemistry.chemical_compound Internal medicine medicine Animals Rats Wistar Antihypertensive Agents Cholesterol business.industry medicine.disease Rats Hypertension Renovascular Blood pressure Endocrinology Liver chemistry Ovariectomized rat Female Geriatrics and Gerontology Steatosis business Oxidation-Reduction Lipoprotein medicine.drug |
| Zdroj: | The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 68:510-520 |
| ISSN: | 1758-535X 1079-5006 |
| DOI: | 10.1093/gerona/gls210 |
| Popis: | Estrogen deficiency is associated with aging and increases the incidence of metabolic syndrome and hypertension. In this study, the effects of tibolone, a synthetic steroid, on the cardiovascular system, liver lipid metabolism, and redox status were evaluated, in ovariectomized (OVX) rats with renovascular hypertension (two-kidneys, one-clip, OVX + 2K1C). This study encompassed direct measurements of mean arterial pressure , plasma biochemical analysis, liver lipid contents, and assessments of the mitochondrial and peroxisomal β-oxidation capacities. Additionally, the liver redox status was assayed. Tibolone significantly reduced the mean arterial pressure of OVX + 2K1C rats, albeit reducing total and high-density lipoprotein (HDL) cholesterol levels. In the liver, although exerting an undesirable inhibition of mitochondrial and peroxisomal β-oxidation, tibolone reversed steatosis. Tibolone also improved the liver redox status: the reduced glutathione contents and the activity of glucose-6-phosphate dehydrogenase were restored by this compound, which also reduced the levels of thiobarbituric acid-reactive substances and the generation of mitochondrial reactive oxygen species. So, tibolone reversed the main alterations caused by hypertension and estrogen deficiency. |
| Databáze: | OpenAIRE |
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