Localization and Elimination of Attentional Dysfunction in Schizophrenia During Visual Search
| Autor: | Geoffrey F. Woodman, Sohee Park, Robert M. G. Reinhart |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Memory Long-Term media_common.quotation_subject medicine.medical_treatment Prefrontal Cortex Transcranial Direct Current Stimulation Neglect 03 medical and health sciences 0302 clinical medicine medicine Humans Visual attention Attention Cognitive Dysfunction Evoked Potentials media_common Visual search Transcranial direct-current stimulation Working memory Attentional control Difficulty focusing Middle Aged Medial frontal cortex 030227 psychiatry Psychiatry and Mental health Memory Short-Term Schizophrenia Visual Perception Female Cues Psychology 030217 neurology & neurosurgery Regular Articles Cognitive psychology |
| Zdroj: | Schizophrenia Bulletin. 45:96-105 |
| ISSN: | 1745-1701 0586-7614 |
| DOI: | 10.1093/schbul/sby002 |
| Popis: | Theories of the locus of visual selective attention dysfunction in schizophrenia propose that the deficits arise from either an inability to maintain working memory representations that guide attention, or difficulty focusing lower-level visual attention mechanisms. However, these theoretical accounts neglect the role of long-term memory representations in controlling attention. Here, we show that the control of visual attention is impaired in people with schizophrenia, and that this impairment is driven by an inability to shift top-down attentional control from working memory to long-term memory across practice. Next, we provide converging evidence for the source of attentional impairments in long-term memory by showing that noninvasive electrical stimulation of medial frontal cortex normalizes long-term memory related neural signatures and patients’ behavior. Our findings suggest that long-term memory structures may be a source of impaired attentional selection in schizophrenia when visual attention is taxed during the processing of multi-object arrays. |
| Databáze: | OpenAIRE |
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