Effects of Low Molecular Weight Sulfated Galactan Fragments From Botryocladia Occidentalis on the Pharmacological and Enzymatic Activity of Spla2 From Crotalus Durissus Cascavella

Autor:	Wladimir Ronald Lobo Farias, Marcos H. Toyama, Daniela de Oliveira Toyama, Grazielle da Costa Pontes, Benildo Sousa Cavada, E. B. S. Diz Filho, Valeska Martins Torres, F. R. Melo, S. C. B. Oliveira, Fábio H. R. Fagundes
Rok vydání:	2010
Předmět:	Male Bioengineering Red algae Galactans Biochemistry Analytical Chemistry Structure-Activity Relationship chemistry.chemical_compound Sulfation Crotalid Venoms Animals Edema Structure–activity relationship Bioorganic chemistry Drug Interactions Mast Cells Rats Wistar Phospholipases A2 Secretory Skin chemistry.chemical_classification biology Sulfates Crotalus Organic Chemistry Galactan biology.organism_classification Enzyme assay Rats Kinetics Enzyme chemistry Rhodophyta biology.protein
Zdroj:	The Protein Journal. 29:567-571
ISSN:	1875-8355 1572-3887
DOI:	10.1007/s10930-010-9294-9
Popis:	Low molecular weight fragments of sulfated galactans (Boc-5 and Boc-10) from the red algae Botryocladia occidentalis significantly inhibited Crotalus durissus cascavella sPLA2 enzymatic activity. Equimolar ratios of sPLA2 to Boc-5 or Boc-10 resulted in allosteric inhibition of sPLA2. Under the conditions tested, we observed that both Boc-5 and Boc-10 strongly decreased edema, myonecrosis, and neurotoxicity induced by native sPLA2.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14dc08eec60988fd06686872a9600426 https://doi.org/10.1007/s10930-010-9294-9 Zobrazit plný text záznamu Full text from SpringerLink