Severity of anaemia and association with all-cause mortality in patients with medically managed left-sided endocarditis
| Autor: | Andreas Birkedal Glenthøj, Emil L. Fosbøl, Claus Moser, Rasmus Bo Hasselbalch, Christoffer Wiingaard, Kurt Fursted, Sabine Gill, Ulrik Christiansen, Nikolaj Ihlemann, Mia Pries-Heje, Jens Jørgen Christensen, Jannik Helweg-Larsen, Niels Eske Bruun, Lars Køber, Jonas Agerlund Povlsen, Kasper Iversen, Flemming S Rosenvinge, Henning Bundgaard, Niels Tønder, Martin Schultz, Lauge Østergaard, Hanne Elming |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Moderate to severe medicine.medical_specialty Valve surgery medicine.drug_class Antibiotics Administration Oral Left sided hemic and lymphatic diseases Internal medicine medicine Humans Endocarditis In patient Aged business.industry biomarkers Anemia Endocarditis Bacterial medicine.disease Anti-Bacterial Agents Infective endocarditis endocarditis Female Cardiology and Cardiovascular Medicine business All cause mortality |
| Zdroj: | Pries-Heje, M M, Hasselbalch, R B, Wiingaard, C, Fosbøl, E L, Glenthøj, A B, Ihlemann, N, Gill, S U A, Christiansen, U, Elming, H, Bruun, N E, Povlsen, J A, Helweg-Larsen, J, Schultz, M, Østergaard, L, Fursted, K, Christensen, J J, Rosenvinge, F, Køber, L, Tønder, N, Moser, C, Iversen, K & Bundgaard, H 2022, ' Severity of anaemia and association with all-cause mortality in patients with medically managed left-sided endocarditis ', Heart, vol. 108, no. 11, pp. 882-888 . https://doi.org/10.1136/heartjnl-2021-319637 |
| ISSN: | 1468-201X 1355-6037 |
| DOI: | 10.1136/heartjnl-2021-319637 |
| Popis: | ObjectiveTo assess the prevalence and severity of anaemia in patients with left-sided infective endocarditis (IE) and association with mortality.MethodsIn the Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis trial, 400 patients with IE were randomised to conventional or partial oral antibiotic treatment after stabilisation of infection, showing non-inferiority. Haemoglobin (Hgb) levels were measured at randomisation. Primary outcomes were all-cause mortality after 6 months and 3 years. Patients who underwent valve surgery were excluded due to competing reasons for anaemia.ResultsOut of 400 patients with IE, 248 (mean age 70.6 years (SD 11.1), 62 women (25.0%)) were medically managed; 37 (14.9%) patients had no anaemia, 139 (56.1%) had mild anaemia (Hgb ConclusionModerate to severe anaemia was present in 29% of patients with medically treated IE after stabilisation of infection and was independently associated with higher mortality within the following 3 years. Further investigations are warranted to determine whether intensified treatment of anaemia in patients with IE might improve outcome. |
| Databáze: | OpenAIRE |
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