Normal spatial learning despite regional inhibition of LTP in mice lacking Thy-1
| Autor: | Colin L. Stewart, R. G. Morris, M. Nosten-Bertrand, D Michalovich, Timothy V. P. Bliss, Y Tokugawa, Elena N. Kozlova, M.L. Errington, Jack Silver, Kerry P.S.J. Murphy, Roger J. Morris, E Barboni |
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| Rok vydání: | 1996 |
| Předmět: |
Male
Long-Term Potentiation Hippocampus Neurotransmission Hippocampal formation Biology gamma-Aminobutyric acid Mice medicine Animals Maze Learning gamma-Aminobutyric Acid Multidisciplinary Cell adhesion molecule musculoskeletal neural and ocular physiology Dentate gyrus Gene targeting Long-term potentiation Mice Inbred C57BL nervous system Dentate Gyrus Gene Targeting Thy-1 Antigens Female Neuroscience medicine.drug |
| Zdroj: | Nature. 379(6568) |
| ISSN: | 0028-0836 |
| Popis: | The process of learning involves stable changes in synaptic efficacy for which long-term potentiation (LTP) provides a widely adopted mammalian model. Synaptic modification induced by learning or LTP may involve the action of cell adhesion molecules. One such candidate is the ubiquitous neuronal glycoprotein Thy-1. In mice in which the gene encoding Thy-1 has been inactivated, we find a regionally selective impairment of LTP in vivo in the hippocampal formation: LTP is normal in area CA1 but strongly inhibited in the dentate gyrus. Spatial learning by Thy-1-deficient mice, as assessed in the watermaze, is unimpaired. Thus LTP in the cortical input to the dentate gyrus seems not to be required for spatial learning. |
| Databáze: | OpenAIRE |
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