Rapid SIV Env-specific mucosal and serum antibody induction augments cellular immunity in protecting immunized, elite-controller macaques against high dose heterologous SIV challenge
| Autor: | L. Jean Patterson, Egidio Brocca-Cofano, Roger W. Wiseman, Marjorie Robert-Guroff, Robert A. Seder, Vaniambadi S. Kalyanaraman, Ulrike Wille-Reece, Ranajit Pal, Stephen Whitney, Jun Zhao, Irene Kalisz, Satya Dandekar, Peng Xiao, David C. Montefiori, Vanessa M. Hirsch, Mario Roederer, Eun Mi Lee, William K. Hu, Mara Daltabuit-Test |
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| Rok vydání: | 2010 |
| Předmět: |
Serum
Cellular immunity animal diseases T-Lymphocytes Simian Acquired Immunodeficiency Syndrome Heterologous Viremia Biology medicine.disease_cause Antibodies Viral Macaque Virus Article Memory Virology biology.animal medicine Animals Immunity Mucosal Immunity Cellular virus diseases Simian immunodeficiency virus medicine.disease Antibodies Neutralizing Macaca mulatta medicine.anatomical_structure Jejunum SIV Immunology Humoral immunity Virus sequestration Simian Immunodeficiency Virus Lymph Nodes Elite-control Multifaceted immunity Vaccine Memory T cell |
| Zdroj: | Virology. 411(1) |
| ISSN: | 1096-0341 |
| Popis: | Three Indian rhesus macaques, Ad-SIV primed/protein boosted and exposed twice to high-dose mucosal SIV mac251 challenges, exhibited elite control of viremia over 6.5 years. They were negative for host factors associated with control of SIV infection. After a third intrarectal challenge with SIV smE660 , all controlled viremia, with one (macaque #5) maintaining undetectable viremia in blood. Acquisition was not blocked, but virus was contained in the jejunum and draining lymph nodes. Polyfunctional memory T cell responses and high-titered neutralizing and non-neutralizing serum and mucosal antibodies were present before and maintained post-challenge. The level of protection seen for animal #5 was predicted from analyses of gene transcription in jejunum 2 weeks post-challenge. Macaques #7 and #9, exhibiting lower pre-challenge cellular and humoral immunity, partially controlled the SIV smE660 challenge. Initial vaccine-induced control by macaque #5 extended to the SIV smE660 challenge due to multiple immune mechanisms that were boosted and augmented by cryptic SIV exposure. |
| Databáze: | OpenAIRE |
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