The behavioral teratogenicity of alcohol is not affected by pretreatment with aspirin
| Autor: | Edward P. Riley, Sarah N. Mattson, Rosa Carlos |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Startle response Reflex Startle Health (social science) Offspring Fetal alcohol syndrome Motor Activity Toxicology Biochemistry Rats Sprague-Dawley Behavioral Neuroscience chemistry.chemical_compound Fetus Internal medicine Avoidance Learning Medicine Animals Aspirin Ethanol medicine.diagnostic_test Behavior Animal business.industry General Medicine medicine.disease Startle reaction Teratology Rats Endocrinology Neurology chemistry Exploratory Behavior Gestation Female business medicine.drug |
| Zdroj: | Alcohol (Fayetteville, N.Y.). 10(1) |
| ISSN: | 0741-8329 |
| Popis: | Prenatal alcohol exposure is associated with a variety of developmental abnormalities, including neuroanatomical, physical, and behavioral features. Several mechanisms for alcohol's teratogenic effects have been proposed. This study addresses the role of prostaglandins in the abnormal development that often occurs after maternal alcohol consumption. On gestation days 8 to 18, pregnant Sprague-Dawley rats were prenatally treated with 6 g/kg alcohol following pretreatment with 150 mg/kg aspirin. Behavioral testing of offspring included measures of open-field activity, exploratory behavior, passive avoidance, active avoidance, and acoustic startle response. In most cases, pretreatment with aspirin did not affect performance in alcohol-exposed or control rats. |
| Databáze: | OpenAIRE |
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