Photocontrolled cargo release from dual cross-linked polymer particles
| Autor: | Katharina Ladewig, Eunhyung Nam, Jing M. Ren, Shereen Tan, Qiang Fu, Edgar H. H. Wong, Greg G. Qiao, Frank Caruso, Jiwei Cui, Anton Blencowe |
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| Přispěvatelé: | Tan, Shereen, Cui, Jiwei, Fu, Qiang, Nam, Eunhyung, Ladewig, Katharina, Ren, Jing M, Wong, Edgar, Caruso, Frank, Blencowe, Anton, Qiao, Greg |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Materials science
particle Cell Survival Polymers Ultraviolet Rays Nanoparticle Biocompatible Materials 02 engineering and technology 010402 general chemistry Microscopy Atomic Force 01 natural sciences Time-Lapse Imaging supramolecular chemistry chemistry.chemical_compound Dynamic light scattering Microscopy Electron Transmission Organic chemistry Humans General Materials Science Nanoscience & Nanotechnology 03 Chemical Sciences 09 Engineering chemistry.chemical_classification Cyclodextrins Food Packaging Polymer 021001 nanoscience & nanotechnology Dynamic Light Scattering 0104 chemical sciences Dextran entrapment chemistry Polymerization Microscopy Fluorescence cyclodextrin Covalent bond Hela Cells polymerization Self-healing hydrogels Biophysics Particle delivery 0210 nano-technology HeLa Cells |
| Popis: | Burst release of a payload from polymeric particles upon photoirradiation was engineered by altering the cross-linking density. This was achieved via a dual cross-linking concept whereby noncovalent cross-linking was provided by cyclodextrin host-guest interactions, and irreversible covalent cross-linking was mediated by continuous assembly of polymers (CAP). The dual cross-linked particles (DCPs) were efficiently infiltrated (∼80-93%) by the biomacromolecule dextran (molecular weight up to 500 kDa) to provide high loadings (70-75%). Upon short exposure (5 s) to UV light, the noncovalent cross-links were disrupted resulting in increased permeability and burst release of the cargo (50 mol % within 1 s) as visualized by time-lapse fluorescence microscopy. As sunlight contains UV light at low intensities, the particles can potentially be incorporated into systems used in agriculture, environmental control, and food packaging, whereby sunlight could control the release of nutrients and antimicrobial agents. Refereed/Peer-reviewed |
| Databáze: | OpenAIRE |
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