Characterization, treatment and prognosis of retinoblastoma with central nervous system metastasis
| Autor: | Yan Zhou, Yi Zhang, Dong-Sheng Huang, Huimin Hu, Yi-Zhuo Wang, Bin Li, Weiling Zhang, Jitong Shi |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Retinal Neoplasms Central nervous system Metastasis Central Nervous System Neoplasms 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid lcsh:Ophthalmology Antineoplastic Combined Chemotherapy Protocols medicine Biomarkers Tumor Humans Child Retrospective Studies Pediatric Chemotherapy Central nervous system metastasis medicine.diagnostic_test Retinoblastoma business.industry Infant Magnetic resonance imaging Optic Nerve General Medicine Chemoradiotherapy medicine.disease Spinal cord Prognosis Survival Analysis Ophthalmology medicine.anatomical_structure lcsh:RE1-994 030220 oncology & carcinogenesis Child Preschool 030221 ophthalmology & optometry Optic nerve Female Radiology business Research Article |
| Zdroj: | BMC Ophthalmology BMC Ophthalmology, Vol 18, Iss 1, Pp 1-7 (2018) |
| ISSN: | 1471-2415 |
| Popis: | Background Retinoblastoma is the most common primary intraocular tumor and more and more attention has been paid to the developing countries. This study was aimed to evaluate the clinical features, treatment, and prognosis of retinoblastoma patients with central nervous system (CNS) metastasis in Beijing Tongren Hospital, one of the largest tertiary eye centers in China. Methods Clinical data of 31 consecutive retinoblastoma patients with CNS metastases, who were diagnosed at the Department of Pediatrics in Beijing Tongren Hospital between September 2005 and December 2015, were retrospective analyzed. Results The median age at presentation was 29 months (range from 5 to 108 months). Magnetic resonance imaging (MRI) results indicated that 16 patients (56.6%, 16/31) presented with meningeal involvement, 12 (38.7%, 12/31) presented with intracranial mass, 11 (35.5%, 11/31) presented with thickened optic nerve, and 5 (16.1%, 5/31) presented with concurrent meningeal and spinal cord membrane involvement. Retinoblastoma cells were detected in the cerebrospinal fluid (CSF) of 12 patients (44.4%, 12/27). Laboratory examinations on the blood and CSF were performed for 11 patients who had received six cycles of systemic chemotherapy, indicated that the serum level of neurone-specific enolase (NSE) after chemotherapy was significantly lower than that before chemotherapy (P |
| Databáze: | OpenAIRE |
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